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Zpbp zona pellucida binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 498415, updated on 2-Nov-2024

Summary

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Symbol
Zpbpprovided by RGD
Full Name
zona pellucida binding proteinprovided by RGD
Primary source
RGD:1563985
See related
EnsemblRapid:ENSRNOG00000027801 AllianceGenome:RGD:1563985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in acrosome assembly and binding activity of sperm to zona pellucida. Predicted to be located in cell body. Predicted to be part of zona pellucida receptor complex. Predicted to be active in acrosomal vesicle. Human ortholog(s) of this gene implicated in spermatogenic failure 66. Orthologous to human ZPBP (zona pellucida binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 181.9), Thymus (RPKM 23.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zpbp in Genome Data Viewer
Location:
14q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (90047207..90244727, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (85830971..86030778, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (91360670..91556406, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 27 Neighboring gene von Willebrand factor C domain containing 2 Neighboring gene uncharacterized LOC102552528 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC120096664 Neighboring gene sperm microtubule inner protein 7 Neighboring gene phosphoglucomutase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The origin and assembly of a zona pellucida binding protein, IAM38, during spermiogenesis. Yu Y, et al. Microsc Res Tech, 2009 Aug. PMID 19204925
  2. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
  3. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. Dun MD, et al. J Biol Chem, 2011 Oct 21. PMID 21880732, Free PMC Article
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of zona pellucida receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zona pellucida receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zona pellucida-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025139.1 → NP_001020310.1  zona pellucida-binding protein 1

    See identical proteins and their annotated locations for NP_001020310.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079315
    UniProtKB/TrEMBL
    F1LRM9, Q6AXU2
    Related
    ENSRNOP00000030318.6, ENSRNOT00000039182.7
    Conserved Domains (1) summary
    pfam07354
    Location:145 → 408
    Sp38; Zona-pellucida-binding protein (Sp38)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    90047207..90244727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273482.1 → XP_063129552.1  zona pellucida-binding protein 1 isoform X2

  2. XM_063273483.1 → XP_063129553.1  zona pellucida-binding protein 1 isoform X3

  3. XM_039092302.2 → XP_038948230.1  zona pellucida-binding protein 1 isoform X4

    Conserved Domains (1) summary
    pfam07354
    Location:178 → 306
    Sp38; Zona-pellucida-binding protein (Sp38)

  4. XM_006251505.5 → XP_006251567.1  zona pellucida-binding protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006251567.1

    UniProtKB/TrEMBL
    A0A8J8XCE4, A6KJ99
    Conserved Domains (1) summary
    pfam07354
    Location:88 → 351
    Sp38; Zona-pellucida-binding protein (Sp38)

  5. XM_039092301.2 → XP_038948229.1  zona pellucida-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam07354
    Location:235 → 363
    Sp38; Zona-pellucida-binding protein (Sp38)

  6. XM_039092305.2 → XP_038948233.1  zona pellucida-binding protein 1 isoform X8

    Conserved Domains (1) summary
    pfam07354
    Location:102 → 230
    Sp38; Zona-pellucida-binding protein (Sp38)

  7. XM_063273485.1 → XP_063129555.1  zona pellucida-binding protein 1 isoform X9

  8. XM_039092304.2 → XP_038948232.1  zona pellucida-binding protein 1 isoform X6

    Conserved Domains (1) summary
    pfam07354
    Location:108 → 236
    Sp38; Zona-pellucida-binding protein (Sp38)

  9. XM_063273484.1 → XP_063129554.1  zona pellucida-binding protein 1 isoform X7

  10. XM_039092306.2 → XP_038948234.1  zona pellucida-binding protein 1 isoform X8

    Conserved Domains (1) summary
    pfam07354
    Location:102 → 230
    Sp38; Zona-pellucida-binding protein (Sp38)
Nucleotide Protein Strain
Heading Accession and Version

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