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Sertad2 SERTA domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498423, updated on 2-Nov-2024

Summary

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Symbol
Sertad2provided by RGD
Full Name
SERTA domain containing 2provided by RGD
Primary source
RGD:1564049
See related
EnsemblRapid:ENSRNOG00000005393 AllianceGenome:RGD:1564049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coactivator activity. Predicted to act upstream of or within negative regulation of cell growth and positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human SERTAD2 (SERTA domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 68.4), Lung (RPKM 62.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sertad2 in Genome Data Viewer
Location:
14q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (98935428..99039536)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (94733637..94838200)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104786649..104890022)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693208 Neighboring gene uncharacterized LOC134481873 Neighboring gene aftiphilin Neighboring gene ribosomal protein S28, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148
  2. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. Hsu SI, et al. EMBO J, 2001 May 1. PMID 11331592, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SERTA domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024903.1 → NP_001020074.2  SERTA domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    BC098047
    UniProtKB/TrEMBL
    A0A8I5ZWR0, F7F8X3
    Related
    ENSRNOP00000085547.2, ENSRNOT00000101884.2
    Conserved Domains (1) summary
    pfam06031
    Location:89 → 126
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    98935428..99039536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251526.5 → XP_006251588.1  SERTA domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006251588.1

    UniProtKB/TrEMBL
    A6JQ25, Q4V7A7
    Related
    ENSRNOP00000097664.1, ENSRNOT00000100709.2
    Conserved Domains (2) summary
    PHA03381
    Location:83 → 172
    PHA03381; tegument protein VP22; Provisional
    pfam06031
    Location:40 → 75
    SERTA; SERTA motif

  2. XM_063273497.1 → XP_063129567.1  SERTA domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0D3
    Related
    ENSRNOP00000007162.5, ENSRNOT00000007162.6

  3. XM_039092326.1 → XP_038948254.1  SERTA domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JQ25, Q4V7A7
    Conserved Domains (2) summary
    PHA03381
    Location:83 → 172
    PHA03381; tegument protein VP22; Provisional
    pfam06031
    Location:40 → 75
    SERTA; SERTA motif

  4. XM_039092325.2 → XP_038948253.1  SERTA domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JQ25, Q4V7A7
    Related
    ENSRNOP00000077181.1, ENSRNOT00000112480.2
    Conserved Domains (2) summary
    PHA03381
    Location:83 → 172
    PHA03381; tegument protein VP22; Provisional
    pfam06031
    Location:40 → 75
    SERTA; SERTA motif

  5. XM_063273498.1 → XP_063129568.1  SERTA domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q4V7A7
    Related
    ENSRNOP00000092548.1, ENSRNOT00000095653.2
Nucleotide Protein Strain
Heading Accession and Version

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