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Shisa2 shisa family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498528, updated on 28-Oct-2024

Summary

Official Symbol
Shisa2provided by RGD
Official Full Name
shisa family member 2provided by RGD
Primary source
RGD:1561256
See related
EnsemblRapid:ENSRNOG00000012521 AllianceGenome:RGD:1561256
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem46; RGD1561256
Summary
Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SHISA2 (shisa family member 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Muscle (RPKM 76.3), Lung (RPKM 29.0) and 5 other tissues See more
Orthologs
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Genomic context

See Shisa2 in Genome Data Viewer
Location:
15p12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (37982913..37987211)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (33806715..33811013)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (39945095..39949393)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481975 Neighboring gene ribosomal protein S9, pseudogene 9 Neighboring gene eukaryotic translation initiation factor 4B, pseudogene 1 Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene uncharacterized LOC134481976

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General protein information

Preferred Names
protein shisa-2 homolog
Names
shisa homolog 2
transmembrane protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191936.1NP_001178865.1  protein shisa-2 homolog precursor

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    D3ZWR8
    Related
    ENSRNOP00000016826.3, ENSRNOT00000016826.7
    Conserved Domains (1) summary
    pfam13908
    Location:35147
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    37982913..37987211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)