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Wwc2 WW and C2 domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498630, updated on 2-May-2024

Summary

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Official Symbol
Wwc2provided by RGD
Official Full Name
WW and C2 domain containing 2provided by RGD
Primary source
RGD:1559427
See related
Ensembl:ENSRNOG00000013248 AllianceGenome:RGD:1559427
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559427
Summary
Predicted to enable kinase binding activity and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of organ growth; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC2 (WW and C2 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 189.5), Lung (RPKM 113.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wwc2 in Genome Data Viewer
Location:
16q11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (50991096..51154529)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44258372..44421815)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47368768..47533816)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a, pseudogene 8 Neighboring gene uncharacterized LOC102551022 Neighboring gene uncharacterized LOC134482501 Neighboring gene claudin 22 Neighboring gene claudin 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, et al. Mol Biol Evol, 2014 Jul. PMID 24682284
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein WWC2
Names
WW, C2 and coiled-coil domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109111.1 → NP_001102581.1  protein WWC2

    See identical proteins and their annotated locations for NP_001102581.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473995
    UniProtKB/TrEMBL
    A6JPK1, D4AEJ5
    Related
    ENSRNOP00000017966.4, ENSRNOT00000017966.6
    Conserved Domains (5) summary
    cd08680
    Location:699 → 822
    C2_Kibra; C2 domain found in Human protein Kibra
    pfam00397
    Location:12 → 41
    WW; WW domain
    pfam11068
    Location:351 → 420
    YlqD; YlqD protein
    cl01720
    Location:1095 → 1153
    Phage_Nu1; Phage DNA packaging protein Nu1
    cl19219
    Location:283 → 385
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    50991096..51154529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275643.1 → XP_063131713.1  protein WWC2 isoform X1

  2. XM_063275644.1 → XP_063131714.1  protein WWC2 isoform X2

  3. XM_039094772.2 → XP_038950700.1  protein WWC2 isoform X3

    Conserved Domains (3) summary
    cd08680
    Location:515 → 638
    C2_Kibra; C2 domain found in Human protein Kibra
    COG1196
    Location:7 → 231
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd06503
    Location:897 → 984
    ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
Nucleotide Protein Strain
Heading Accession and Version

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