U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prxl2c peroxiredoxin like 2C [ Rattus norvegicus (Norway rat) ]

Gene ID: 498685, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Prxl2cprovided by RGD
Official Full Name
peroxiredoxin like 2Cprovided by RGD
Primary source
RGD:1589650
See related
EnsemblRapid:ENSRNOG00000018886 AllianceGenome:RGD:1589650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aaed1
Summary
Predicted to be involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. Orthologous to human PRXL2C (peroxiredoxin like 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 95.0), Heart (RPKM 89.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Prxl2c in Genome Data Viewer
Location:
17p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (817932..849965)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (812199..839536)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1798224..1830011, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3-like Neighboring gene cathepsin L Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA serine (anticodon AGA) 40 Neighboring gene cell division cycle 14B Neighboring gene uncharacterized LOC134482653 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. AAED1 modulates proliferation and glycolysis in gastric cancer. Zhang B, et al. Oncol Rep, 2018 Aug. PMID 29901208
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peroxiredoxin-like 2C
Names
AhpC/TSA antioxidant enzyme domain containing 1
thioredoxin-like protein AAED1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399210.1 → NP_001386139.1  peroxiredoxin-like 2C isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6G5D2, A6KQE1
    Related
    ENSRNOP00000079468.1, ENSRNOT00000109028.2
    Conserved Domains (1) summary
    cd02970
    Location:34 → 195
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  2. NM_001399211.1 → NP_001386140.1  peroxiredoxin-like 2C isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6A506
    Related
    ENSRNOP00000086014.1, ENSRNOT00000104207.2
    Conserved Domains (1) summary
    cd02970
    Location:34 → 168
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    817932..849965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095988.2 → XP_038951916.1  peroxiredoxin-like 2C isoform X2

    Conserved Domains (1) summary
    cd02970
    Location:34 → 134
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  2. XM_063276679.1 → XP_063132749.1  peroxiredoxin-like 2C isoform X3

    UniProtKB/TrEMBL
    A6KQD9, D3ZAK1

  3. XM_039095987.2 → XP_038951915.1  peroxiredoxin-like 2C isoform X1

    Related
    ENSRNOP00000062637.2, ENSRNOT00000066230.3
    Conserved Domains (1) summary
    cd02970
    Location:34 → 192
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RNA

  1. XR_010058909.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001109114.1: Suppressed sequence

    Description
    NM_001109114.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools