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Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 498690, updated on 17-Aug-2024

Summary

Official Symbol
Ctla2aprovided by RGD
Official Full Name
cytotoxic T lymphocyte-associated protein 2 alphaprovided by RGD
Primary source
RGD:1565540
See related
EnsemblRapid:ENSRNOG00000039971 AllianceGenome:RGD:1565540
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565540
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 63.9), Thymus (RPKM 43.1) and 7 other tissues See more
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Genomic context

Location:
17p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (3809052..3828872)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (3803844..3805729)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (4169696..4194700)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cathepsin M like 1 Neighboring gene trophoblast specific protein alpha Neighboring gene testin gene Neighboring gene thioredoxin-related transmembrane protein 3, pseudogene 1 Neighboring gene cathepsin L-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109115.1NP_001102585.1  protein CTLA-2-alpha

    See identical proteins and their annotated locations for NP_001102585.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474032
    UniProtKB/TrEMBL
    A6KAE9, A6KAF1, D3ZHI6
    Conserved Domains (1) summary
    smart00848
    Location:1674
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    3809052..3828872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276680.1XP_063132750.1  protein CTLA-2-alpha isoform X1

    Related
    ENSRNOP00000102408.1, ENSRNOT00000168437.1
  2. XM_063276681.1XP_063132751.1  protein CTLA-2-alpha isoform X2

    UniProtKB/TrEMBL
    A6KAE9, A6KAF1, D3ZHI6