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Jcad junctional cadherin 5 associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 498764, updated on 2-Nov-2024

Summary

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Official Symbol
Jcadprovided by RGD
Official Full Name
junctional cadherin 5 associatedprovided by RGD
Primary source
RGD:1562037
See related
EnsemblRapid:ENSRNOG00000027938 AllianceGenome:RGD:1562037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562037
Summary
Predicted to be involved in several processes, including positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of cell migration involved in sprouting angiogenesis; and positive regulation of signal transduction. Predicted to be located in cell-cell junction and perinuclear region of cytoplasm. Predicted to be active in adherens junction and ruffle membrane. Orthologous to human JCAD (junctional cadherin 5 associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 226.5), Heart (RPKM 139.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Jcad in Genome Data Viewer
Location:
17q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (57784634..57826213, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (53089382..53130996, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (55667754..55709738, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556228 Neighboring gene uncharacterized LOC120097795 Neighboring gene uncharacterized LOC102557539 Neighboring gene uncharacterized LOC108348576 Neighboring gene uncharacterized LOC120097757

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Hara T, et al. Arterioscler Thromb Vasc Biol, 2017 Sep. PMID 28705794
  2. A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. Akashi M, et al. Biochem Biophys Res Commun, 2011 Sep 23. PMID 21884682
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
junctional cadherin 5-associated protein
Names
junctional protein associated with coronary artery disease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427709.1 → NP_001414638.1  junctional cadherin 5-associated protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6K9F8, F1M6T3
    Related
    ENSRNOP00000035031.5, ENSRNOT00000033359.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    57784634..57826213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096446.2 → XP_038952374.1  junctional cadherin 5-associated protein isoform X1

    UniProtKB/TrEMBL
    A6K9F8, F1M6T3
    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1320
    JCAD; Junctional protein associated with coronary artery disease

  2. XM_039096447.2 → XP_038952375.1  junctional cadherin 5-associated protein isoform X1

    UniProtKB/TrEMBL
    A6K9F8, F1M6T3
    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1320
    JCAD; Junctional protein associated with coronary artery disease

  3. XM_039096448.2 → XP_038952376.1  junctional cadherin 5-associated protein isoform X1

    UniProtKB/TrEMBL
    A6K9F8, F1M6T3
    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1320
    JCAD; Junctional protein associated with coronary artery disease

  4. XM_008771790.4 → XP_008770012.2  junctional cadherin 5-associated protein isoform X2

    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1182
    JCAD; Junctional protein associated with coronary artery disease

  5. XM_008771786.4 → XP_008770008.2  junctional cadherin 5-associated protein isoform X2

    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1182
    JCAD; Junctional protein associated with coronary artery disease

  6. XM_008771788.4 → XP_008770010.2  junctional cadherin 5-associated protein isoform X2

    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1182
    JCAD; Junctional protein associated with coronary artery disease

  7. XM_063276696.1 → XP_063132766.1  junctional cadherin 5-associated protein isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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