AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: AKR1C3l1provided by RGD
Official Full Name: aldo-keto reductase family 1 member C3-like 1provided by RGD
Primary source: RGD:1564865
See related: EnsemblRapid:ENSRNOG00000038361 AllianceGenome:RGD:1564865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309566; RGD1564865
Summary: Predicted to enable bile acid binding activity; ketosteroid monooxygenase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including doxorubicin metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 901.5) See more
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Genomic context

Location:: 17q12.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (70745496..70791411)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (65847580..65881488)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (69468427..69497132)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of aldo-keto reductase 1C subfamily members encoded in two rat genes (akr1c19 and RGD1564865). Relationship to 9-hydroxyprostaglandin dehydrogenase.
Title: Characterization of aldo-keto reductase 1C subfamily members encoded in two rat genes (akr1c19 and RGD1564865). Relationship to 9-hydroxyprostaglandin dehydrogenase.
Ethylene glycol monomethyl ether, sulpiride, or atrazine downregulated the luteolytic gene, 20-alpha-Hydroxysteroid Dehydrogenase.
Title: Differential stimulation pathways of progesterone secretion from newly formed corpora lutea in rats treated with ethylene glycol monomethyl ether, sulpiride, or atrazine.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member C3-like 1

Names: 20-alpha-hydroxysteroid dehydrogenase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164396.1 → NP_001157868.1 aldo-keto reductase family 1 member C3-like 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I5ZMV2, A0A8I6ADN4

Related

ENSRNOP00000079498.1, ENSRNOT00000096835.2

Conserved Domains (2) summary

COG0656
Location:8 → 311

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:19 → 297

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

70745496..70791411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276697.1 → XP_063132767.1 aldo-keto reductase family 1 member C3-like 1 isoform X1

UniProtKB/TrEMBL

F1LU12

Related

ENSRNOP00000055214.3, ENSRNOT00000058413.5
XM_063276698.1 → XP_063132768.1 aldo-keto reductase family 1 member C3-like 1 isoform X2

Related

ENSRNOP00000094993.2, ENSRNOT00000106629.2
XM_063276699.1 → XP_063132769.1 aldo-keto reductase family 1 member C3-like 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AN46
XM_063276700.1 → XP_063132770.1 aldo-keto reductase family 1 member C3-like 1 isoform X4