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Thnsl1 threonine synthase-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498805, updated on 19-Sep-2024

Summary

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Official Symbol
Thnsl1provided by RGD
Official Full Name
threonine synthase-like 1provided by RGD
Primary source
RGD:1564213
See related
EnsemblRapid:ENSRNOG00000033076 AllianceGenome:RGD:1564213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be active in cytoplasm. Orthologous to human THNSL1 (threonine synthase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 61.9), Brain (RPKM 61.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thnsl1 in Genome Data Viewer
Location:
17q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (88623054..88630681)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (83714794..83722190)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (88095830..88102264)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550221 Neighboring gene uncharacterized LOC134482761 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene ribosomal protein S8 like 1 Neighboring gene G protein-coupled receptor 158 Neighboring gene uncharacterized LOC102549062

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
threonine synthase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025035.1 → NP_001020206.1  threonine synthase-like 1

    See identical proteins and their annotated locations for NP_001020206.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091213
    UniProtKB/TrEMBL
    Q5BK42
    Related
    ENSRNOP00000106210.1, ENSRNOT00000165785.1
    Conserved Domains (4) summary
    cd01560
    Location:230 → 733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK00131
    Location:56 → 223
    aroK; shikimate kinase; Reviewed
    PRK09225
    Location:231 → 739
    PRK09225; threonine synthase; Validated
    cd00464
    Location:57 → 204
    SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    88623054..88630681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096029.2 → XP_038951957.1  threonine synthase-like 1 isoform X1

    UniProtKB/TrEMBL
    E9PTK4
    Related
    ENSRNOP00000054444.2, ENSRNOT00000045984.6
    Conserved Domains (2) summary
    cd01560
    Location:230 → 733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    pfam01202
    Location:64 → 221
    SKI; Shikimate kinase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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