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Greb1l GREB1 like retinoic acid receptor coactivator [ Rattus norvegicus (Norway rat) ]

Gene ID: 498819, updated on 28-Oct-2024

Summary

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Official Symbol
Greb1lprovided by RGD
Official Full Name
GREB1 like retinoic acid receptor coactivatorprovided by RGD
Primary source
RGD:1562371
See related
EnsemblRapid:ENSRNOG00000023492 AllianceGenome:RGD:1562371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562371
Summary
Predicted to act upstream of or within several processes, including kidney development; paramesonephric duct development; and reproductive structure development. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 38.0), Kidney (RPKM 33.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Greb1l in Genome Data Viewer
Location:
18p13
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1665468..1902291)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1392330..1629483)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1537315..1784260)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC3-like Neighboring gene ribosomal protein L36A, pseudogene 10 Neighboring gene SAP domain containing ribonucleoprotein, pseudogene 2 Neighboring gene heat shock protein family D (Hsp60) member 1 like 1 Neighboring gene protein RCC2-like Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene ATP synthase membrane subunit G like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Sanna-Cherchi S, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100090, Free PMC Article
  2. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. De Tomasi L, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100091, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac ventricle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male genitalia development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mesonephric duct development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metanephros development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paramesonephric duct development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within uterus development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GREB1 like retinoic acid receptor coactivator; GREB1-like protein
Names
growth regulation by estrogen in breast cancer 1 like
growth regulation by estrogen in breast cancer-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432470.1 → NP_001419399.1  GREB1 like retinoic acid receptor coactivator

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LTR0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    1665468..1902291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097272.2 → XP_038953200.1  GREB1-like protein isoform X3

    UniProtKB/TrEMBL
    A6KNE1
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1888
    GREB1; Gene regulated by oestrogen in breast cancer

  2. XM_039097267.2 → XP_038953195.1  GREB1-like protein isoform X1

    UniProtKB/TrEMBL
    A6KNE1
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1955
    GREB1; Gene regulated by oestrogen in breast cancer

  3. XM_039097268.2 → XP_038953196.1  GREB1-like protein isoform X1

    UniProtKB/TrEMBL
    A6KNE1
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1955
    GREB1; Gene regulated by oestrogen in breast cancer

  4. XM_039097265.2 → XP_038953193.1  GREB1-like protein isoform X1

    UniProtKB/TrEMBL
    A6KNE1
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1955
    GREB1; Gene regulated by oestrogen in breast cancer

  5. XM_039097270.2 → XP_038953198.1  GREB1-like protein isoform X2

    Related
    ENSRNOP00000109265.1, ENSRNOT00000156299.1
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1912
    GREB1; Gene regulated by oestrogen in breast cancer

  6. XM_039097269.2 → XP_038953197.1  GREB1-like protein isoform X1

    UniProtKB/TrEMBL
    A6KNE1
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1955
    GREB1; Gene regulated by oestrogen in breast cancer

  7. XM_039097266.2 → XP_038953194.1  GREB1-like protein isoform X1

    UniProtKB/TrEMBL
    A6KNE1
    Related
    ENSRNOP00000029000.8, ENSRNOT00000033468.8
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1955
    GREB1; Gene regulated by oestrogen in breast cancer
Nucleotide Protein Strain
Heading Accession and Version

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