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Tmem170a transmembrane protein 170A [ Rattus norvegicus (Norway rat) ]

Gene ID: 498953, updated on 17-Aug-2024

Summary

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Official Symbol
Tmem170aprovided by RGD
Official Full Name
transmembrane protein 170Aprovided by RGD
Primary source
RGD:1559505
See related
AllianceGenome:RGD:1559505
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559505
Summary
Predicted to be involved in endoplasmic reticulum tubular network organization; nuclear envelope organization; and nuclear pore complex assembly. Predicted to be located in nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMEM170A (transmembrane protein 170A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 35.1), Kidney (RPKM 34.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem170a in Genome Data Viewer
Location:
19q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56743221..56756085, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39833947..39846807, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44090418..44101365, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene BCAR1 scaffold protein, Cas family member Neighboring gene craniofacial development protein 1 Neighboring gene uncharacterized LOC134483372 Neighboring gene U6 spliceosomal RNA Neighboring gene carbohydrate sulfotransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells. Christodoulou A, et al. J Cell Sci, 2016 Apr 15. PMID 26906412, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear pore complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 170A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134608.1 → NP_001128080.1  transmembrane protein 170A

    See identical proteins and their annotated locations for NP_001128080.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IZB2, M0R417
    Conserved Domains (1) summary
    pfam10190
    Location:39 → 144
    Tmemb_170; Putative transmembrane protein 170

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    56743221..56756085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097934.2 → XP_038953862.1  transmembrane protein 170A isoform X1

    Conserved Domains (1) summary
    pfam10190
    Location:39 → 121
    Tmemb_170; Putative transmembrane protein 170
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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