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Coa4 cytochrome c oxidase assembly factor 4 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 499214, updated on 2-Nov-2024

Summary

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Official Symbol
Coa4provided by RGD
Official Full Name
cytochrome c oxidase assembly factor 4 homologprovided by RGD
Primary source
RGD:1562228
See related
EnsemblRapid:ENSRNOG00000077991 AllianceGenome:RGD:1562228
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Chchd8; RGD1562228
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human COA4 (cytochrome c oxidase assembly factor 4 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 80.4), Adrenal (RPKM 78.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coa4 in Genome Data Viewer
Location:
1q32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164294312..164297571)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154882199..154885445)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165549319..165552573)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691200 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene uncharacterized LOC120099893 Neighboring gene uncharacterized LOC120099894 Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene RAB6A, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells. Fischer M, et al. Mol Biol Cell, 2013 Jul. PMID 23676665, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188692

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 8
Names
coiled-coil-helix-coiled-coil-helix domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127655.1 → NP_001121127.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 8

    See identical proteins and their annotated locations for NP_001121127.1

    Status: PROVISIONAL

    Source sequence(s)
    BC159412
    UniProtKB/TrEMBL
    A0A8I6GLA4, B0K013
    Related
    ENSRNOP00000111648.1, ENSRNOT00000142826.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    164294312..164297571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229782.5 → XP_006229844.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 8 isoform X1

  2. XM_006229783.5 → XP_006229845.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006229845.1

    UniProtKB/TrEMBL
    A0A8I6GLA4, B0K013
Nucleotide Protein Strain
Heading Accession and Version

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