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Rit1 Ras-like without CAAX 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499652, updated on 2-Nov-2024

Summary

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Official Symbol
Rit1provided by RGD
Official Full Name
Ras-like without CAAX 1provided by RGD
Primary source
RGD:1559874
See related
EnsemblRapid:ENSRNOG00000064584 AllianceGenome:RGD:1559874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559874
Summary
Predicted to enable GTPase activity; calmodulin binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 286.4), Heart (RPKM 202.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rit1 in Genome Data Viewer
Location:
2q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176478616..176493269)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174180742..174195455)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188087486..188099444)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene RNA, U6 small nuclear 632 Neighboring gene synaptotagmin 11 Neighboring gene gon-4 like Neighboring gene misato mitochondrial distribution and morphology regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib. Song Z, et al. Cancer Lett, 2019 Sep 28. PMID 31247273
  2. RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis. Feng YF, et al. Cell Death Dis, 2018 Oct 22. PMID 30348939, Free PMC Article
  3. Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia. Cavé H, et al. Eur J Hum Genet, 2016 Aug. PMID 26757980, Free PMC Article
  4. Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. Yaoita M, et al. Hum Genet, 2016 Feb. PMID 26714497
  5. Next-generation sequencing identifies rare variants associated with Noonan syndrome. Chen PC, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049390, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP-binding protein Rit1
NP_001383470.1
NP_001383471.1
NP_001383477.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396541.1 → NP_001383470.1  GTP-binding protein Rit1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ABM0, A6J699, A6J6A2
    Conserved Domains (1) summary
    cd04141
    Location:20 → 191
    Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

  2. NM_001396542.1 → NP_001383471.1  GTP-binding protein Rit1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ABM0, A6J699, A6J6A2
    Conserved Domains (1) summary
    cd04141
    Location:20 → 191
    Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

  3. NM_001396548.1 → NP_001383477.1  GTP-binding protein Rit1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ABM0, A6J699, A6J6A2
    Related
    ENSRNOP00000090769.1, ENSRNOT00000099308.2
    Conserved Domains (1) summary
    cd04141
    Location:20 → 191
    Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176478616..176493269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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