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Garnl3 GTPase activating Rap/RanGAP domain-like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499783, updated on 2-Nov-2024

Summary

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Official Symbol
Garnl3provided by RGD
Official Full Name
GTPase activating Rap/RanGAP domain-like 3provided by RGD
Primary source
RGD:1564019
See related
EnsemblRapid:ENSRNOG00000057044 AllianceGenome:RGD:1564019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564019
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be active in cytoplasm. Orthologous to human GARNL3 (GTPase activating Rap/RanGAP domain like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 109.1), Kidney (RPKM 30.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Garnl3 in Genome Data Viewer
Location:
3p11
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36686388..36830011, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16288718..16432308, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (12034131..12176591, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12 Neighboring gene uncharacterized LOC120101525 Neighboring gene solute carrier family 2 member 8 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2 Neighboring gene zinc finger and BTB domain containing 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTPase activating Rap/RanGAP domain-like 3; GTPase-activating Rap/Ran-GAP domain-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430652.1 → NP_001417581.1  GTPase activating Rap/RanGAP domain-like 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001430653.1 → NP_001417582.1  GTPase activating Rap/RanGAP domain-like 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001430654.1 → NP_001417583.1  GTPase activating Rap/RanGAP domain-like 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ALW8

  4. NM_001430655.1 → NP_001417584.1  GTPase activating Rap/RanGAP domain-like 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZUD1

  5. NM_001430656.1 → NP_001417585.1  GTPase activating Rap/RanGAP domain-like 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A905

  6. NM_001430657.1 → NP_001417586.1  GTPase activating Rap/RanGAP domain-like 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  7. NM_001430658.1 → NP_001417587.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  8. NM_001430659.1 → NP_001417588.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  9. NM_001430660.1 → NP_001417589.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  10. NM_001430661.1 → NP_001417590.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  11. NM_001430662.1 → NP_001417591.1  GTPase activating Rap/RanGAP domain-like 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  12. NM_001430663.1 → NP_001417592.1  GTPase activating Rap/RanGAP domain-like 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  13. NM_001430664.1 → NP_001417593.1  GTPase activating Rap/RanGAP domain-like 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36686388..36830011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106188.2 → XP_038962116.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X2

    Related
    ENSRNOP00000086495.2, ENSRNOT00000114726.2
    Conserved Domains (2) summary
    pfam00780
    Location:552 → 857
    CNH; CNH domain
    pfam02145
    Location:280 → 458
    Rap_GAP; Rap/ran-GAP

  2. XM_063284843.1 → XP_063140913.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ALW8
    Related
    ENSRNOP00000094574.2, ENSRNOT00000101955.2

  3. XM_063284848.1 → XP_063140918.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ALW8

  4. XM_063284845.1 → XP_063140915.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X5

  5. XM_039106187.2 → XP_038962115.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X1

    Related
    ENSRNOP00000082025.2, ENSRNOT00000099420.2
    Conserved Domains (2) summary
    pfam00780
    Location:556 → 861
    CNH; CNH domain
    pfam02145
    Location:284 → 462
    Rap_GAP; Rap/ran-GAP

  6. XM_063284849.1 → XP_063140919.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X3

  7. XM_039106201.2 → XP_038962129.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

    Conserved Domains (2) summary
    pfam00780
    Location:324 → 629
    CNH; CNH domain
    pfam02145
    Location:52 → 230
    Rap_GAP; Rap/ran-GAP

  8. XM_039106197.2 → XP_038962125.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

    Conserved Domains (2) summary
    pfam00780
    Location:324 → 629
    CNH; CNH domain
    pfam02145
    Location:52 → 230
    Rap_GAP; Rap/ran-GAP

  9. XM_039106200.2 → XP_038962128.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JX90
    Conserved Domains (2) summary
    pfam00780
    Location:324 → 629
    CNH; CNH domain
    pfam02145
    Location:52 → 230
    Rap_GAP; Rap/ran-GAP

  10. XM_039106195.2 → XP_038962123.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X6

    Related
    ENSRNOP00000070180.3, ENSRNOT00000082696.3
    Conserved Domains (2) summary
    pfam00780
    Location:471 → 776
    CNH; CNH domain
    pfam02145
    Location:199 → 377
    Rap_GAP; Rap/ran-GAP

  11. XM_063284850.1 → XP_063140920.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

  12. XM_039106202.2 → XP_038962130.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

    Conserved Domains (2) summary
    pfam00780
    Location:324 → 629
    CNH; CNH domain
    pfam02145
    Location:52 → 230
    Rap_GAP; Rap/ran-GAP

  13. XM_039106198.2 → XP_038962126.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X9

    Conserved Domains (2) summary
    pfam00780
    Location:324 → 629
    CNH; CNH domain
    pfam02145
    Location:52 → 230
    Rap_GAP; Rap/ran-GAP

  14. XM_063284846.1 → XP_063140916.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X7

  15. XM_063284844.1 → XP_063140914.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X4

    Related
    ENSRNOP00000107399.1, ENSRNOT00000130540.1

  16. XM_063284847.1 → XP_063140917.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X8

RNA

  1. XR_010064757.1 RNA Sequence

  2. XR_010064759.1 RNA Sequence

  3. XR_010064758.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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