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Dcaf17 DDB1 and CUL4 associated factor 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499807, updated on 10-Oct-2024

Summary

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Official Symbol
Dcaf17provided by RGD
Official Full Name
DDB1 and CUL4 associated factor 17provided by RGD
Primary source
RGD:1565551
See related
EnsemblRapid:ENSRNOG00000009403 AllianceGenome:RGD:1565551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565551
Summary
Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Woodhouse-Sakati syndrome. Orthologous to human DCAF17 (DDB1 and CUL4 associated factor 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 82.6), Lung (RPKM 77.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dcaf17 in Genome Data Viewer
Location:
3q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76271503..76303321)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55863776..55895601)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57646799..57678802)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 8, tRNA N3-cytidine Neighboring gene uncharacterized LOC134486104 Neighboring gene uncharacterized LOC134486103 Neighboring gene cytochrome b reductase 1 Neighboring gene uncharacterized LOC134486105 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177688.2 → NP_001171159.1  DDB1- and CUL4-associated factor 17 isoform 1

    See identical proteins and their annotated locations for NP_001171159.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    B1H299
    UniProtKB/TrEMBL
    A0A140TAE5
    Conserved Domains (1) summary
    pfam15802
    Location:31 → 473
    DCAF17; DDB1- and CUL4-associated factor 17

  2. NM_001398928.1 → NP_001385857.1  DDB1- and CUL4-associated factor 17 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM38
    Related
    ENSRNOP00000097480.2, ENSRNOT00000098494.2
    Conserved Domains (1) summary
    pfam15802
    Location:31 → 504
    DCAF17; DDB1- and CUL4-associated factor 17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    76271503..76303321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284357.1 → XP_063140427.1  DDB1- and CUL4-associated factor 17 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AV09
    Related
    ENSRNOP00000031374.7, ENSRNOT00000031463.7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1H299.1 GenPept UniProtKB/Swiss-Prot:B1H299

Gene LinkOut

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