Prrg4 proline rich and Gla domain 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prrg4provided by RGD
Official Full Name: proline rich and Gla domain 4provided by RGD
Primary source: RGD:1560542
See related: EnsemblRapid:ENSRNOG00000022710 AllianceGenome:RGD:1560542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560542
Summary: Predicted to enable WW domain binding activity. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PRRG4 (proline rich and Gla domain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 149.5), Thymus (RPKM 68.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (111669508..111698205, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (91214646..91243347, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (94783866..94808861, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D3Got42 (e-PCR)
- UniSTS:115787

D3Got44 (e-PCR)
- UniSTS:113064

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane gamma-carboxyglutamic acid protein 4

Names: proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109203.1 → NP_001102673.1 transmembrane gamma-carboxyglutamic acid protein 4 precursor

See identical proteins and their annotated locations for NP_001102673.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/TrEMBL

A0A8I5ZRJ1, A6HNV3, D3ZZA9

Related

ENSRNOP00000032611.4, ENSRNOT00000038464.6

Conserved Domains (1) summary

pfam00594
Location:57 → 97

Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

111669508..111698205 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234655.4 → XP_006234717.1 transmembrane gamma-carboxyglutamic acid protein 4 isoform X1

See identical proteins and their annotated locations for XP_006234717.1

UniProtKB/TrEMBL

A0A8I5ZRJ1, A6HNV3, D3ZZA9

Conserved Domains (1) summary

pfam00594
Location:57 → 97

Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain