Gins1 GINS complex subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gins1provided by RGD
Official Full Name: GINS complex subunit 1provided by RGD
Primary source: RGD:1562246
See related: EnsemblRapid:ENSRNOG00000008091 AllianceGenome:RGD:1562246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562246
Summary: Predicted to be involved in DNA strand elongation involved in mitotic DNA replication. Predicted to act upstream of or within DNA replication and inner cell mass cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of GINS complex. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 98.5), Spleen (RPKM 61.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (160184920..160206334)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (139724513..139745930)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (146695366..146716787)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA strand elongation involved in mitotic DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CMG complex	ISO Inferred from Sequence Orthology more info
part_of GINS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GINS complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA replication complex GINS protein PSF1

Names: GINS complex subunit 1 (Psf1 homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109207.2 → NP_001102677.2 DNA replication complex GINS protein PSF1

See identical proteins and their annotated locations for NP_001102677.2

Status: VALIDATED

Source sequence(s)

BC166989

UniProtKB/TrEMBL

A6KHH3, B2RZ16, F7EXT9

Related

ENSRNOP00000010955.3, ENSRNOT00000010955.7

Conserved Domains (2) summary

cd11710
Location:3 → 130

GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1

COG5230
Location:1 → 191

COG5230; Uncharacterized conserved protein [Function unknown]