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Uckl1 uridine-cytidine kinase 1-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499956, updated on 2-Nov-2024

Summary

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Official Symbol
Uckl1provided by RGD
Official Full Name
uridine-cytidine kinase 1-like 1provided by RGD
Primary source
RGD:1565465
See related
EnsemblRapid:ENSRNOG00000050277 AllianceGenome:RGD:1565465
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565465
Summary
Predicted to enable ATP binding activity and uridine kinase activity. Predicted to be involved in CTP salvage; UMP salvage; and phosphorylation. Predicted to be active in cytoplasm. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 90.0), Thymus (RPKM 56.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uckl1 in Genome Data Viewer
Location:
3q43
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189052365..189064939, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168674849..168687513, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177066022..177078611, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548047 Neighboring gene TPD52 like 2 Neighboring gene ribosomal protein L34-like2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene zinc finger protein 512B Neighboring gene sterile alpha motif domain containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CTP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uridine-cytidine kinase-like 1
NP_001102682.1
XP_006235855.1
XP_006235856.1
XP_006235857.1
XP_006235858.1
XP_038961641.1
XP_038961642.1
XP_038961643.1
XP_038961645.1
XP_038961646.1
XP_038961647.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109212.1 → NP_001102682.1  uridine-cytidine kinase-like 1

    See identical proteins and their annotated locations for NP_001102682.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474066
    UniProtKB/TrEMBL
    A6KLZ1, D3ZYQ8
    Related
    ENSRNOP00000020695.6, ENSRNOT00000020695.8
    Conserved Domains (2) summary
    cd02023
    Location:101 → 299
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:329 → 532
    UPRTase; Uracil phosphoribosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    189052365..189064939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105713.2 → XP_038961641.1  uridine-cytidine kinase-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GA89, D3ZYQ8
    Related
    ENSRNOP00000084349.1, ENSRNOT00000112230.2
    Conserved Domains (2) summary
    cd02023
    Location:101 → 299
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:330 → 533
    UPRTase; Uracil phosphoribosyltransferase

  2. XM_039105714.2 → XP_038961642.1  uridine-cytidine kinase-like 1 isoform X2

    UniProtKB/TrEMBL
    D3ZYQ8
    Conserved Domains (2) summary
    cd02023
    Location:100 → 298
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:329 → 532
    UPRTase; Uracil phosphoribosyltransferase

  3. XM_039105715.2 → XP_038961643.1  uridine-cytidine kinase-like 1 isoform X3

    UniProtKB/TrEMBL
    D3ZYQ8
    Related
    ENSRNOP00000094809.2, ENSRNOT00000113965.2
    Conserved Domains (2) summary
    cd02023
    Location:100 → 298
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:328 → 531
    UPRTase; Uracil phosphoribosyltransferase

  4. XM_006235795.5 → XP_006235857.1  uridine-cytidine kinase-like 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZVU1
    Conserved Domains (2) summary
    cd02023
    Location:85 → 283
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:314 → 517
    UPRTase; Uracil phosphoribosyltransferase

  5. XM_039105717.2 → XP_038961645.1  uridine-cytidine kinase-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZVU1
    Conserved Domains (2) summary
    cd02023
    Location:85 → 283
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:313 → 516
    UPRTase; Uracil phosphoribosyltransferase

  6. XM_006235793.5 → XP_006235855.1  uridine-cytidine kinase-like 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVU1, A0A8I6AIR8
    Conserved Domains (3) summary
    COG0572
    Location:78 → 291
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:86 → 284
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:315 → 518
    UPRTase; Uracil phosphoribosyltransferase

  7. XM_006235794.5 → XP_006235856.1  uridine-cytidine kinase-like 1 isoform X5

    See identical proteins and their annotated locations for XP_006235856.1

    UniProtKB/TrEMBL
    A0A8I5Y757, A0A8I5ZVU1, A6KLZ3
    Conserved Domains (2) summary
    cd02023
    Location:86 → 284
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:314 → 517
    UPRTase; Uracil phosphoribosyltransferase

  8. XM_006235796.5 → XP_006235858.1  uridine-cytidine kinase-like 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GJU6
    Conserved Domains (3) summary
    COG0572
    Location:57 → 270
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:65 → 263
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:294 → 497
    UPRTase; Uracil phosphoribosyltransferase

  9. XM_039105719.2 → XP_038961647.1  uridine-cytidine kinase-like 1 isoform X10

    Conserved Domains (1) summary
    cd02023
    Location:101 → 299
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  10. XM_039105718.2 → XP_038961646.1  uridine-cytidine kinase-like 1 isoform X9

    Conserved Domains (1) summary
    cd02023
    Location:101 → 299
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RNA

  1. XR_005501969.2 RNA Sequence

  2. XR_010064686.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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