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Thsd7a thrombospondin type 1 domain containing 7A [ Rattus norvegicus (Norway rat) ]

Gene ID: 500032, updated on 17-Aug-2024

Summary

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Official Symbol
Thsd7aprovided by RGD
Official Full Name
thrombospondin type 1 domain containing 7Aprovided by RGD
Primary source
RGD:1566201
See related
EnsemblRapid:ENSRNOG00000030151 AllianceGenome:RGD:1566201
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566201
Summary
Predicted to be involved in actin cytoskeleton reorganization. Predicted to be located in podocyte foot. Predicted to be active in plasma membrane. Orthologous to human THSD7A (thrombospondin type 1 domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 67.1), Uterus (RPKM 52.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q21
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (41427276..41865524, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (40461124..40899345, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (38658512..39103411, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102235 Neighboring gene PHD finger protein 14 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 60 kDa heat shock protein, mitochondrial pseudogene Neighboring gene ribosomal protein S2, pseudogene 40 Neighboring gene uncharacterized LOC108350856 Neighboring gene pyruvate kinase M1/2, pseudogene 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats. Aktepe OH, et al. Turk J Gastroenterol, 2021 Dec. PMID 34876395, Free PMC Article
  2. Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. Tomas NM, et al. J Clin Invest, 2016 Jul 1. PMID 27214550, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats.
    Title: Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in podocyte foot ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thrombospondin type-1 domain-containing protein 7A
Names
thrombospondin, type I, domain containing 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191970.2 → NP_001178899.2  thrombospondin type-1 domain-containing protein 7A precursor

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IDZ3, F1MA97
    Related
    ENSRNOP00000040000.6, ENSRNOT00000052063.7
    Conserved Domains (2) summary
    pfam19028
    Location:184 → 235
    TSP1_spondin; Spondin-like TSP1 domain
    pfam19030
    Location:1088 → 1151
    TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    41427276..41865524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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