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Lrrc61 leucine rich repeat containing 61 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500111, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc61provided by RGD
Official Full Name
leucine rich repeat containing 61provided by RGD
Primary source
RGD:1561800
See related
EnsemblRapid:ENSRNOG00000008234 AllianceGenome:RGD:1561800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561800
Summary
Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Orthologous to human LRRC61 (leucine rich repeat containing 61). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 399.0), Lung (RPKM 58.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrc61 in Genome Data Viewer
Location:
4q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78834783..78854810)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77503882..77523909)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78186181..78206818)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 862 Neighboring gene ATPase, H+ transporting V0 subunit e2 Neighboring gene retinoic acid receptor responder 2 Neighboring gene hypothetical LOC100363281 Neighboring gene replication initiator 1 Neighboring gene zinc finger protein 775

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109231.2 → NP_001102701.1  leucine-rich repeat-containing protein 61

    See identical proteins and their annotated locations for NP_001102701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6K0F7, D3ZA60
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:49 → 166
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. NM_001395079.1 → NP_001382008.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6K0F7, D3ZA60
    Related
    ENSRNOP00000083792.1, ENSRNOT00000097373.2
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:49 → 166
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    78834783..78854810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236437.5 → XP_006236499.1  leucine-rich repeat-containing protein 61 isoform X1

    See identical proteins and their annotated locations for XP_006236499.1

    UniProtKB/TrEMBL
    A6K0F7, D3ZA60
    Related
    ENSRNOP00000010864.3, ENSRNOT00000010864.6
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:49 → 166
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_039108124.1 → XP_038964052.1  leucine-rich repeat-containing protein 61 isoform X1

    UniProtKB/TrEMBL
    A6K0F7, D3ZA60
    Related
    ENSRNOP00000092465.1, ENSRNOT00000115463.2
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:49 → 166
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_006236436.3 → XP_006236498.1  leucine-rich repeat-containing protein 61 isoform X1

    See identical proteins and their annotated locations for XP_006236498.1

    UniProtKB/TrEMBL
    A6K0F7, D3ZA60
    Related
    ENSRNOP00000100457.1, ENSRNOT00000144264.1
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:49 → 166
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  4. XM_039108125.2 → XP_038964053.1  leucine-rich repeat-containing protein 61 isoform X1

    UniProtKB/TrEMBL
    A6K0F7, D3ZA60
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:49 → 166
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version

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