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Tra2a transformer 2 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 500116, updated on 17-Aug-2024

Summary

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Official Symbol
Tra2aprovided by RGD
Official Full Name
transformer 2 alphaprovided by RGD
Primary source
RGD:1562563
See related
EnsemblRapid:ENSRNOG00000009156 AllianceGenome:RGD:1562563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562563
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of mRNA splicing, via spliceosome. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 205.6), Spleen (RPKM 152.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79551699..79570621, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (78220838..78239737, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78905380..78924203, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene gem (nuclear organelle) associated protein 7-like 1 Neighboring gene prothymosin alpha, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Tacke R, et al. Cell, 1998 Apr 3. PMID 9546399
  2. Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. Grellscheid S, et al. PLoS Genet, 2011 Dec. PMID 22194695, Free PMC Article
  3. Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1. Lieberman AP, et al. Biochem Biophys Res Commun, 2001 Mar 30. PMID 11401487
  4. Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript. Park E, et al. J Biol Chem, 2006 Jan 6. PMID 16249178
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transformer-2 protein homolog alpha
Names
transformer 2 alpha homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126296.2 → NP_001119768.2  transformer-2 protein homolog alpha

    See identical proteins and their annotated locations for NP_001119768.2

    Status: VALIDATED

    Source sequence(s)
    BC161978, JAXUCZ010000004
    UniProtKB/TrEMBL
    B1WC25, F7ESB6
    Related
    ENSRNOP00000012325.9, ENSRNOT00000012325.9
    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    79551699..79570621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236465.5 → XP_006236527.1  transformer-2 protein homolog alpha isoform X4

    See identical proteins and their annotated locations for XP_006236527.1

    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  2. XM_063286511.1 → XP_063142581.1  transformer-2 protein homolog alpha isoform X7

  3. XM_063286510.1 → XP_063142580.1  transformer-2 protein homolog alpha isoform X6

  4. XM_063286509.1 → XP_063142579.1  transformer-2 protein homolog alpha isoform X3

    UniProtKB/TrEMBL
    A0A8J8Y9E0
    Related
    ENSRNOP00000082266.2, ENSRNOT00000096480.2

  5. XM_039108127.2 → XP_038964055.1  transformer-2 protein homolog alpha isoform X1

    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  6. XM_006236466.4 → XP_006236528.1  transformer-2 protein homolog alpha isoform X5

    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  7. XM_006236464.4 → XP_006236526.1  transformer-2 protein homolog alpha isoform X2

    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  8. XM_017592792.3 → XP_017448281.1  transformer-2 protein homolog alpha isoform X8

    Conserved Domains (1) summary
    cd12363
    Location:17 → 96
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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