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Stk31 serine threonine kinase 31 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500120, updated on 18-Sep-2024

Summary

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Official Symbol
Stk31provided by RGD
Official Full Name
serine threonine kinase 31provided by RGD
Primary source
RGD:1564384
See related
EnsemblRapid:ENSRNOG00000057554 AllianceGenome:RGD:1564384
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564384
Summary
Predicted to enable protein kinase activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in acrosomal vesicle. Predicted to be active in cytoplasm. Orthologous to human STK31 (serine/threonine kinase 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 127.1) See more
Orthologs
human mouse all
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Genomic context

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See Stk31 in Genome Data Viewer
Location:
4q24
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79701470..79797085)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (78370691..78467599)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (79055493..79153849)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 221, member A Neighboring gene ribosomal protein S11 like 1 Neighboring gene uncharacterized LOC120102266 Neighboring gene uncharacterized LOC120102267

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein. Bao J, et al. Histochem Cell Biol, 2012 Mar. PMID 22205278
  2. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Zhou J, et al. Hum Mol Genet, 2015 Nov 15. PMID 26362258, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 31
NP_001178900.1
XP_038964060.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191971.1 → NP_001178900.1  serine/threonine-protein kinase 31

    See identical proteins and their annotated locations for NP_001178900.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5ZLI1, A0A8I6AF45
    Related
    ENSRNOP00000078757.1, ENSRNOT00000105358.2
    Conserved Domains (3) summary
    cd04508
    Location:89 → 129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29 → 147
    TUDOR; Tudor domain
    cl21453
    Location:803 → 922
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    79701470..79797085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108132.2 → XP_038964060.1  serine/threonine-protein kinase 31 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWJ2, A0A8I5ZLI1
    Related
    ENSRNOP00000069902.2, ENSRNOT00000086307.3
    Conserved Domains (3) summary
    COG0419
    Location:301 → 696
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd20430
    Location:65 → 139
    Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
    cl21453
    Location:807 → 926
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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