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Mmrn1 multimerin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500152, updated on 2-Nov-2024

Summary

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Official Symbol
Mmrn1provided by RGD
Official Full Name
multimerin 1provided by RGD
Primary source
RGD:1587248
See related
EnsemblRapid:ENSRNOG00000024986 AllianceGenome:RGD:1587248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable extracellular matrix constituent conferring elasticity. Predicted to be involved in cell adhesion mediated by integrin; negative regulation of wound healing; and positive regulation of platelet aggregation. Predicted to be located in collagen-containing extracellular matrix; extracellular region; and platelet alpha granule. Predicted to be part of multimerin complex. Orthologous to human MMRN1 (multimerin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 80.1), Lung (RPKM 73.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mmrn1 in Genome Data Viewer
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (91205462..91280862)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (89875408..89950814)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (90977537..91038747)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene synuclein alpha Neighboring gene enolase 1, pseudogene 7 Neighboring gene protein phosphatase 6, catalytic subunit, pseuidogene 1 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix constituent conferring elasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
part_of multimerin complex ISO
Inferred from Sequence Orthology
more info
  
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
multimerin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427207.1 → NP_001414136.1  multimerin-1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6KF09, D4A3E0
    Related
    ENSRNOP00000035433.4, ENSRNOT00000030320.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    91205462..91280862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236596.5 → XP_006236658.1  multimerin-1 isoform X2

    See identical proteins and their annotated locations for XP_006236658.1

    Conserved Domains (4) summary
    cd00054
    Location:1026 → 1058
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    TIGR04523
    Location:311 → 851
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam07546
    Location:195 → 262
    EMI; EMI domain
    cl23878
    Location:1075 → 1209
    C1q; C1q domain

  2. XM_001071128.8 → XP_001071128.2  multimerin-1 isoform X1

    See identical proteins and their annotated locations for XP_001071128.2

    UniProtKB/TrEMBL
    A6KF09, D4A3E0
    Conserved Domains (4) summary
    cd00054
    Location:1027 → 1059
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    TIGR04523
    Location:311 → 851
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam07546
    Location:195 → 262
    EMI; EMI domain
    cl23878
    Location:1076 → 1210
    C1q; C1q domain
Nucleotide Protein Strain
Heading Accession and Version

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