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Aak1 AP2 associated kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500244, updated on 2-Nov-2024

Summary

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Official Symbol
Aak1provided by RGD
Official Full Name
AP2 associated kinase 1provided by RGD
Primary source
RGD:1305520
See related
EnsemblRapid:ENSRNOG00000018317 AllianceGenome:RGD:1305520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563580
Summary
Enables AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in presynaptic endocytosis and regulation of clathrin-dependent endocytosis. Located in cell leading edge and terminal bouton. Part of clathrin complex. Is active in calyx of Held. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 315.7), Adrenal (RPKM 93.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aak1 in Genome Data Viewer
Location:
4q34
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120845012..121009170)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119300128..119451834)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118653851..118806796)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene annexin A4 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene uncharacterized LOC134486606 Neighboring gene uncharacterized LOC134486605 Neighboring gene ribosomal protein L22, pseudogene 2 Neighboring gene uncharacterized LOC134486608 Neighboring gene uncharacterized LOC120102328 Neighboring gene NFU1 iron-sulfur cluster scaffold Neighboring gene glutamine fructose-6-phosphate transaminase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. miRNA-384-3p alleviates sevoflurane-induced nerve injury by inhibiting Aak1 kinase in neonatal rats. Chen Y, et al. Brain Behav, 2022 Jul. PMID 35726359, Free PMC Article
  2. The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. Gupta-Rossi N, et al. J Biol Chem, 2011 May 27. PMID 21464124, Free PMC Article
  3. AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis. Sorensen EB, et al. Traffic, 2008 Sep. PMID 18657069
  4. A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. Henderson DM, et al. Mol Biol Cell, 2007 Jul. PMID 17494869, Free PMC Article
  5. AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. Conner SD, et al. Traffic, 2003 Dec. PMID 14617351

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miRNA-384-3p alleviates sevoflurane-induced nerve injury by inhibiting Aak1 kinase in neonatal rats.
    Title: miRNA-384-3p alleviates sevoflurane-induced nerve injury by inhibiting Aak1 kinase in neonatal rats.
  2. This study demonistrated that AAK1 contributes to dendrite growth regulation.
    Title: Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
  3. AAK1 is a relevant target of K252a, that the loss of AAK1 alters ErbB4 trafficking and expression levels, providing evidence for a previously unrecognized role for AAK1 in Nrg1-mediated neurotrophic factor signaling.
    Title: AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables AP-2 adaptor complex binding IEA
Inferred from Electronic Annotation
more info
  
enables AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Notch binding IEA
Inferred from Electronic Annotation
more info
  
enables Notch binding ISO
Inferred from Sequence Orthology
more info
  
enables Notch binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in presynaptic endocytosis EXP
Inferred from Experiment
more info
 PubMed 
involved_in presynaptic endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in calyx of Held EXP
Inferred from Experiment
more info
 PubMed 
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
part_of clathrin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AP2-associated protein kinase 1
Names
adaptor-associated kinase 1
NP_001166921.1
XP_006236895.1
XP_006236896.1
XP_017448306.1
XP_017448307.1
XP_017448308.1
XP_017448309.1
XP_017448310.1
XP_017448311.1
XP_038964087.1
XP_038964088.1
XP_038964089.1
XP_038964090.1
XP_063142600.1
XP_063142601.1
XP_063142602.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173450.1 → NP_001166921.1  AP2-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001166921.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P0C1X8
    UniProtKB/TrEMBL
    F1LRI7
    Related
    ENSRNOP00000044665.4, ENSRNOT00000043082.6
    Conserved Domains (2) summary
    smart00220
    Location:47 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    120845012..121009170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592818.3 → XP_017448307.1  AP2-associated protein kinase 1 isoform X1

  2. XM_017592822.3 → XP_017448311.1  AP2-associated protein kinase 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I6A256
    Related
    ENSRNOP00000084865.1, ENSRNOT00000118607.2

  3. XM_006236833.5 → XP_006236895.1  AP2-associated protein kinase 1 isoform X12

    See identical proteins and their annotated locations for XP_006236895.1

    UniProtKB/Swiss-Prot
    P0C1X8
    UniProtKB/TrEMBL
    F1LRI7
    Conserved Domains (2) summary
    smart00220
    Location:47 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  4. XM_017592817.3 → XP_017448306.1  AP2-associated protein kinase 1 isoform X1

  5. XM_017592820.3 → XP_017448309.1  AP2-associated protein kinase 1 isoform X4

    Related
    ENSRNOP00000078415.2, ENSRNOT00000104791.2

  6. XM_039108160.2 → XP_038964088.1  AP2-associated protein kinase 1 isoform X5

    Conserved Domains (3) summary
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam05109
    Location:320 → 423
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15282
    Location:982 → 1193
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  7. XM_039108159.2 → XP_038964087.1  AP2-associated protein kinase 1 isoform X3

    Conserved Domains (3) summary
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam05109
    Location:320 → 423
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15282
    Location:1058 → 1269
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  8. XM_039108161.2 → XP_038964089.1  AP2-associated protein kinase 1 isoform X7

    Conserved Domains (3) summary
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam05109
    Location:320 → 423
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15282
    Location:950 → 1161
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  9. XM_017592819.3 → XP_017448308.1  AP2-associated protein kinase 1 isoform X2

    Related
    ENSRNOP00000088529.2, ENSRNOT00000102896.2

  10. XM_063286530.1 → XP_063142600.1  AP2-associated protein kinase 1 isoform X6

  11. XM_017592821.3 → XP_017448310.1  AP2-associated protein kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6ALS6
    Related
    ENSRNOP00000094963.1, ENSRNOT00000096717.2

  12. XM_063286531.1 → XP_063142601.1  AP2-associated protein kinase 1 isoform X9

  13. XM_039108162.2 → XP_038964090.1  AP2-associated protein kinase 1 isoform X11

    Conserved Domains (3) summary
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam05109
    Location:320 → 423
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15282
    Location:915 → 1126
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  14. XM_063286532.1 → XP_063142602.1  AP2-associated protein kinase 1 isoform X14

  15. XM_006236834.5 → XP_006236896.1  AP2-associated protein kinase 1 isoform X13

    UniProtKB/Swiss-Prot
    P0C1X8
    Conserved Domains (2) summary
    smart00220
    Location:47 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C1X8.1 GenPept UniProtKB/Swiss-Prot:P0C1X8

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