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Tafa1 TAFA chemokine like family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500266, updated on 2-Nov-2024

Summary

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Symbol
Tafa1provided by RGD
Full Name
TAFA chemokine like family member 1provided by RGD
Primary source
RGD:1563030
See related
EnsemblRapid:ENSRNOG00000070575 AllianceGenome:RGD:1563030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam19a1; RGD1563030
Summary
Predicted to enable receptor ligand activity. Predicted to be involved in neuroblast differentiation; regulation of neuroblast proliferation; and regulation of signaling receptor activity. Predicted to be located in endoplasmic reticulum and extracellular space. Orthologous to human TAFA1 (TAFA chemokine like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 60.1), Spleen (RPKM 18.8) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tafa1 in Genome Data Viewer
Location:
4q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (130294659..130799139)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (128738028..129244223)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (128818468..128942088)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene NOP2 nucleolar protein, pseudogene 4 Neighboring gene uncharacterized LOC102549269 Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 7 Neighboring gene nucleoporin 50, pseudogene 1 Neighboring gene uncharacterized LOC120102500 Neighboring gene uncharacterized LOC120102499 Neighboring gene RNA, U6 small nuclear 131 Neighboring gene TAFA chemokine like family member 4 Neighboring gene uncharacterized LOC134486820 Neighboring gene uncharacterized LOC134486821

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation. Zheng C, et al. FASEB J, 2018 May 25. PMID 29799787

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neuroblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TAFA chemokine like family member 1; chemokine-like protein TAFA-1
Names
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
family with sequence similarity 19 member A1, C-C motif chemokine like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431830.1 → NP_001418759.1  TAFA chemokine like family member 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5ZYE4

  2. NM_001431831.1 → NP_001418760.1  TAFA chemokine like family member 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5ZYE4

  3. NM_001431832.1 → NP_001418761.1  TAFA chemokine like family member 1 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    130294659..130799139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109030.2 → XP_038964958.1  chemokine-like protein TAFA-1 isoform X2

    Related
    ENSRNOP00000083056.1, ENSRNOT00000097372.2
    Conserved Domains (1) summary
    pfam12020
    Location:41 → 129
    TAFA; TAFA family

  2. XM_039109032.2 → XP_038964960.1  chemokine-like protein TAFA-1 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:40 → 128
    TAFA; TAFA family

  3. XM_039109031.2 → XP_038964959.1  chemokine-like protein TAFA-1 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:41 → 129
    TAFA; TAFA family
Nucleotide Protein Strain
Heading Accession and Version

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