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Parp11 poly (ADP-ribose) polymerase family, member 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500323, updated on 2-Nov-2024

Summary

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Official Symbol
Parp11provided by RGD
Official Full Name
poly (ADP-ribose) polymerase family, member 11provided by RGD
Primary source
RGD:1561791
See related
EnsemblRapid:ENSRNOG00000060689 AllianceGenome:RGD:1561791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561791
Summary
Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in protein auto-ADP-ribosylation. Predicted to act upstream of or within nuclear envelope organization. Predicted to be located in cytosol; nuclear body; and nuclear envelope. Orthologous to human PARP11 (poly(ADP-ribose) polymerase family member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 40.2), Brain (RPKM 29.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Parp11 in Genome Data Viewer
Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161984192..162030550)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (160298040..160344369)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (160013968..160059981)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102394 Neighboring gene ribosomal protein L26, pseudogene 6 Neighboring gene uncharacterized LOC134486844 Neighboring gene calcium release activated channel regulator 2A Neighboring gene protein arginine methyltransferase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice. Meyer-Ficca ML, et al. Biol Reprod, 2015 Mar. PMID 25673562, Free PMC Article
  2. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, et al. Mol Cell, 2015 Jun 18. PMID 26091342
  3. Family-wide analysis of poly(ADP-ribose) polymerase activity. Vyas S, et al. Nat Commun, 2014 Jul 21. PMID 25043379, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP11
Names
poly [ADP-ribose] polymerase 11
NP_001414716.1
XP_038964754.1
XP_038964757.1
XP_038964758.1
XP_038964760.1
XP_063142641.1
XP_063142642.1
XP_063142643.1
XP_063142644.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427787.2 → NP_001414716.1  protein mono-ADP-ribosyltransferase PARP11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JTL9
    Related
    ENSRNOP00000068762.2, ENSRNOT00000078802.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    161984192..162030550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286574.1 → XP_063142644.1  protein mono-ADP-ribosyltransferase PARP11 isoform X5

  2. XM_063286571.1 → XP_063142641.1  protein mono-ADP-ribosyltransferase PARP11 isoform X2

  3. XM_063286573.1 → XP_063142643.1  protein mono-ADP-ribosyltransferase PARP11 isoform X3

  4. XM_039108830.2 → XP_038964758.1  protein mono-ADP-ribosyltransferase PARP11 isoform X3

    Conserved Domains (1) summary
    cd01439
    Location:111 → 247
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  5. XM_039108826.2 → XP_038964754.1  protein mono-ADP-ribosyltransferase PARP11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTL9
    Conserved Domains (2) summary
    smart00678
    Location:27 → 107
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:194 → 330
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  6. XM_039108829.2 → XP_038964757.1  protein mono-ADP-ribosyltransferase PARP11 isoform X3

    Conserved Domains (1) summary
    cd01439
    Location:111 → 247
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  7. XM_063286572.1 → XP_063142642.1  protein mono-ADP-ribosyltransferase PARP11 isoform X3

  8. XM_039108832.2 → XP_038964760.1  protein mono-ADP-ribosyltransferase PARP11 isoform X4

    Conserved Domains (1) summary
    cd01439
    Location:77 → 213
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
Nucleotide Protein Strain
Heading Accession and Version

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