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Irag2 inositol 1,4,5-triphosphate receptor associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500361, updated on 2-Nov-2024

Summary

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Official Symbol
Irag2provided by RGD
Official Full Name
inositol 1,4,5-triphosphate receptor associated 2provided by RGD
Primary source
RGD:1562062
See related
EnsemblRapid:ENSRNOG00000029308 AllianceGenome:RGD:1562062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrmp; RGD1562062
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in nucleus organization. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Orthologous to human IRAG2 (inositol 1,4,5-triphosphate receptor associated 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 200.0), Thymus (RPKM 161.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Irag2 in Genome Data Viewer
Location:
4q44
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (179819526..179874408)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (178088902..178143569)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (179402929..179440792)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene branched chain amino acid transaminase 1 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene uncharacterized LOC134486864 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene KRAS proto-oncogene, GTPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells. Shindo Y, et al. Chem Senses, 2010 Feb. PMID 20071408, Free PMC Article
  2. Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. Behrens TW, et al. J Immunol, 1994 Jul 15. PMID 8021504
  3. Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum. Behrens TW, et al. J Biol Chem, 1996 Sep 20. PMID 8798562
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleus organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inositol 1,4,5-triphosphate receptor associated 2
Names
lymphoid-restricted membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427185.2 → NP_001414114.2  inositol 1,4,5-triphosphate receptor associated 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    179819526..179874408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286587.1 → XP_063142657.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X4

    UniProtKB/TrEMBL
    A6IMZ5, F1LXR9

  2. XM_063286579.1 → XP_063142649.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

  3. XM_063286589.1 → XP_063142659.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X5

  4. XM_063286580.1 → XP_063142650.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

  5. XM_063286590.1 → XP_063142660.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X6

  6. XM_063286591.1 → XP_063142661.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X7

  7. XM_063286583.1 → XP_063142653.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X2

    Related
    ENSRNOP00000046606.7, ENSRNOT00000049474.8

  8. XM_063286586.1 → XP_063142656.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

  9. XM_063286592.1 → XP_063142662.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6G5Y4
    Related
    ENSRNOP00000081442.1, ENSRNOT00000093893.2

  10. XM_063286584.1 → XP_063142654.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

  11. XM_063286593.1 → XP_063142663.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6G5Y4

  12. XM_063286581.1 → XP_063142651.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

  13. XM_063286582.1 → XP_063142652.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

  14. XM_063286585.1 → XP_063142655.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

  15. XM_063286594.1 → XP_063142664.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6G5Y4

  16. XM_063286588.1 → XP_063142658.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X4

    UniProtKB/TrEMBL
    A6IMZ5, F1LXR9
    Related
    ENSRNOP00000102134.1, ENSRNOT00000150781.1
Nucleotide Protein Strain
Heading Accession and Version

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