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Sspn sarcospan [ Rattus norvegicus (Norway rat) ]

Gene ID: 500364, updated on 2-Nov-2024

Summary

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Symbol
Sspnprovided by RGD
Full Name
sarcospanprovided by RGD
Primary source
RGD:1559723
See related
EnsemblRapid:ENSRNOG00000001807 AllianceGenome:RGD:1559723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559723
Summary
Predicted to be located in plasma membrane and transport vesicle. Predicted to be part of dystrophin-associated glycoprotein complex. Predicted to be active in sarcolemma. Orthologous to human SSPN (sarcospan). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 430.8), Muscle (RPKM 241.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sspn in Genome Data Viewer
Location:
4q44
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (180620762..180666893)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (178890030..178946267)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180291389..180325799)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 8 Neighboring gene basic helix-loop-helix family, member e41 Neighboring gene uncharacterized LOC102549898 Neighboring gene uncharacterized LOC134486658 Neighboring gene inositol 1,4,5-trisphosphate receptor, type 2 Neighboring gene uncharacterized LOC134486659

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Caveolin-3 deficiency causes muscle degeneration in mice. Hagiwara Y, et al. Hum Mol Genet, 2000 Dec 12. PMID 11115849
  2. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Coral-Vazquez R, et al. Cell, 1999 Aug 20. PMID 10481911
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of dystrophin-associated glycoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sarcospan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109255.2 → NP_001102725.1  sarcospan

    See identical proteins and their annotated locations for NP_001102725.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IN14, D4ABT9
    Related
    ENSRNOP00000002465.3, ENSRNOT00000002465.6
    Conserved Domains (1) summary
    pfam04103
    Location:37 → 183
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    180620762..180666893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108232.2 → XP_038964160.1  sarcospan isoform X2

    Conserved Domains (1) summary
    pfam04103
    Location:9 → 107
    CD20; CD20-like family

  2. XM_039108233.2 → XP_038964161.1  sarcospan isoform X3

    Conserved Domains (1) summary
    pfam04103
    Location:37 → 96
    CD20; CD20-like family

  3. XM_017592843.3 → XP_017448332.1  sarcospan isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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