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Tpm2 tropomyosin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500450, updated on 2-Nov-2024

Summary

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Official Symbol
Tpm2provided by RGD
Official Full Name
tropomyosin 2provided by RGD
Primary source
RGD:1559479
See related
EnsemblRapid:ENSRNOG00000016731 AllianceGenome:RGD:1559479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATP-dependent activity. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 16460.3) See more
Orthologs
human mouse all
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Genomic context

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See Tpm2 in Genome Data Viewer
Location:
5q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62566712..62576066, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57770919..57780278, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59016616..59025971, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 107 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene carbonic anhydrase 9 Neighboring gene uncharacterized LOC134486933 Neighboring gene talin 1 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosylceramidase beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat embryonic fibroblast tropomyosin 1. cDNA and complete primary amino acid sequence. Yamawaki-Kataoka Y, et al. J Biol Chem, 1985 Nov 25. PMID 3840484
  2. Nonmuscle and muscle tropomyosin isoforms are expressed from a single gene by alternative RNA splicing and polyadenylation. Helfman DM, et al. Mol Cell Biol, 1986 Nov. PMID 2432392, Free PMC Article
  3. Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2. Hsu WL, et al. BMC Biol, 2017 Nov 28. PMID 29183317, Free PMC Article
  4. In vitro formation and characterization of the skeletal muscle α·β tropomyosin heterodimers. Kalyva A, et al. Biochemistry, 2012 Aug 14. PMID 22812662, Free PMC Article
  5. Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly. Gimona M, et al. Proc Natl Acad Sci U S A, 1995 Oct 10. PMID 7568216, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109519

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tropomyosin beta chain
Names
beta-tropomyosin
tropomyosin 2, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024345.2 → NP_001019516.1  tropomyosin beta chain isoform Tpm2.1sm/cy

    See identical proteins and their annotated locations for NP_001019516.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm2.1, also known as variant 2) has an alternate internal exon and an alternate 3' exon, as compared to variant Tpm2.2. The resulting isoform (Tpm2.1sm/cy, also known as isoform 2) has a different internal segment and a different C-terminus, but has the same protein size, as compared to isoform Tpm2.2st.
    Source sequence(s)
    CF110059, CV796622, FQ223760
    UniProtKB/TrEMBL
    Q5FVG5
    Related
    ENSRNOP00000044473.4, ENSRNOT00000049000.8
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  2. NM_001301235.1 → NP_001288164.1  tropomyosin beta chain isoform Tpm2.2st

    See identical proteins and their annotated locations for NP_001288164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm2.2, also known as variant 1) represents the longer transcript and encodes isoform Tpm2.2st (also known as isoform 1), which has the same protein size as isoform Tpm2.1sm/cy.
    Source sequence(s)
    FQ118075, FQ217483, FQ223760
    UniProtKB/Swiss-Prot
    P06395, P58775
    Related
    ENSRNOP00000022801.6, ENSRNOT00000022801.8
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    62566712..62576066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763680.2 → XP_008761902.1  tropomyosin beta chain isoform X1

    See identical proteins and their annotated locations for XP_008761902.1

    UniProtKB/TrEMBL
    A6IJ28
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  2. XM_008763681.2 → XP_008761903.1  tropomyosin beta chain isoform X2

    See identical proteins and their annotated locations for XP_008761903.1

    Related
    ENSRNOP00000080861.1, ENSRNOT00000102327.2
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58775.1 GenPept UniProtKB/Swiss-Prot:P58775

Gene LinkOut

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