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Caap1 caspase activity and apoptosis inhibitor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500501, updated on 2-Nov-2024

Summary

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Symbol
Caap1provided by RGD
Full Name
caspase activity and apoptosis inhibitor 1provided by RGD
Primary source
RGD:1560251
See related
EnsemblRapid:ENSRNOG00000007299 AllianceGenome:RGD:1560251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 65.8), Spleen (RPKM 59.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Caap1 in Genome Data Viewer
Location:
5q33
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (114428991..114530047, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (109313253..109414323, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (113479416..113532961, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102919 Neighboring gene large ribosomal subunit protein uL2-like Neighboring gene uncharacterized LOC120102920 Neighboring gene phospholipase A2, activating protein Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. Zhang Y, et al. PLoS One, 2011. PMID 21980415, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC125002

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caspase activity and apoptosis inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034154.4 → NP_001029326.2  caspase activity and apoptosis inhibitor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  2. NM_001415955.1 → NP_001402884.1  caspase activity and apoptosis inhibitor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JRG2, G3V6Y7, Q3KR90
    Related
    ENSRNOP00000010173.5, ENSRNOT00000010173.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    114428991..114530047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288234.1 → XP_063144304.1  caspase activity and apoptosis inhibitor 1 isoform X1

RNA

  1. XR_005504518.2 RNA Sequence

  2. XR_010066459.1 RNA Sequence

  3. XR_010066458.1 RNA Sequence

  4. XR_005504515.2 RNA Sequence

  5. XR_010066455.1 RNA Sequence

  6. XR_010066456.1 RNA Sequence

  7. XR_010066454.1 RNA Sequence

  8. XR_005504514.2 RNA Sequence

  9. XR_010066453.1 RNA Sequence

  10. XR_010066457.1 RNA Sequence

  11. XR_010066452.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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