U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lin28a lin-28 homolog A [ Rattus norvegicus (Norway rat) ]

Gene ID: 500562, updated on 2-Nov-2024

Summary

Symbol
Lin28aprovided by RGD
Full Name
lin-28 homolog Aprovided by RGD
Primary source
RGD:1566408
See related
EnsemblRapid:ENSRNOG00000082489 AllianceGenome:RGD:1566408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lin28; RGD1566408
Summary
Predicted to enable RNA binding activity; protein-RNA adaptor activity; and translation initiation factor binding activity. Predicted to be involved in several processes, including RNA metabolic process; positive regulation of intracellular signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including miRNA metabolic process; negative regulation of glial cell differentiation; and regulation of gene expression. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; nucleolus; and rough endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human LIN28A (lin-28 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 3.2), Testes (RPKM 1.9) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Lin28a in Genome Data Viewer
Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151510891..151527884, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146227119..146244122, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152230343..152247873, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene dehydrodolichyl diphosphate synthase subunit Neighboring gene uncharacterized LOC134487000 Neighboring gene zinc finger protein 683 Neighboring gene crystallin beta-gamma domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-quadruplex RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-RNA adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA 3' uridylation ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell proliferation involved in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein lin-28 homolog A
Names
protein lin-28 homolog A-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109269.1NP_001102739.1  protein lin-28 homolog A

    See identical proteins and their annotated locations for NP_001102739.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6ISZ6, D3ZZA6
    Related
    ENSRNOP00000108329.1, ENSRNOT00000141154.1
    Conserved Domains (2) summary
    COG5082
    Location:120183
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
    pfam00313
    Location:42112
    CSD; 'Cold-shock' DNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    151510891..151527884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)