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Tc2n tandem C2 domains, nuclear [ Rattus norvegicus (Norway rat) ]

Gene ID: 500707, updated on 2-Nov-2024

Summary

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Official Symbol
Tc2nprovided by RGD
Official Full Name
tandem C2 domains, nuclearprovided by RGD
Primary source
RGD:1563876
See related
EnsemblRapid:ENSRNOG00000004754 AllianceGenome:RGD:1563876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tac2-N; Mtac2d1
Summary
Predicted to be active in nucleus. Orthologous to human TC2N (tandem C2 domains, nuclear). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 266.2), Uterus (RPKM 65.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tc2n in Genome Data Viewer
Location:
6q32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (126526006..126622163, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120761112..120856835, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (125437767..125601408, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene neugrin, neurite outgrowth associated, pseudogene 2 Neighboring gene uncharacterized LOC134479250 Neighboring gene fibulin 5 Neighboring gene thyroid hormone receptor interactor 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. Fukuda M, et al. FEBS Lett, 2001 Aug 17. PMID 11526914
  2. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. Antoni G, et al. BMC Med Genet, 2011 Aug 2. PMID 21810271, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tandem C2 domains nuclear protein
Names
membrane targeting (tandem) C2 domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025152.1 → NP_001020323.1  tandem C2 domains nuclear protein

    See identical proteins and their annotated locations for NP_001020323.1

    Status: VALIDATED

    Source sequence(s)
    BC088432
    UniProtKB/TrEMBL
    A0A8I5Y9B0, E9PTC2, Q5M7U8
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    126526006..126622163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112744.2 → XP_038968672.1  tandem C2 domains nuclear protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y9B0, E9PTC2, Q5M7U8
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  2. XM_063262331.1 → XP_063118401.1  tandem C2 domains nuclear protein isoform X4

  3. XM_039112750.2 → XP_038968678.1  tandem C2 domains nuclear protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y9B0, E9PTC2, Q5M7U8
    Related
    ENSRNOP00000006371.6, ENSRNOT00000006371.9
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  4. XM_063262332.1 → XP_063118402.1  tandem C2 domains nuclear protein isoform X4

  5. XM_039112747.2 → XP_038968675.1  tandem C2 domains nuclear protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y9B0, E9PTC2, Q5M7U8
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  6. XM_008764836.2 → XP_008763058.1  tandem C2 domains nuclear protein isoform X2

    See identical proteins and their annotated locations for XP_008763058.1

    UniProtKB/TrEMBL
    A0A8I5Y9B0, E9PTC2, Q5M7U8
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  7. XM_039112745.2 → XP_038968673.1  tandem C2 domains nuclear protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y9B0, E9PTC2, Q5M7U8
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  8. XM_063262329.1 → XP_063118399.1  tandem C2 domains nuclear protein isoform X2

    UniProtKB/TrEMBL
    E9PTC2, Q5M7U8

  9. XM_063262322.1 → XP_063118392.1  tandem C2 domains nuclear protein isoform X1

  10. XM_063262323.1 → XP_063118393.1  tandem C2 domains nuclear protein isoform X1

  11. XM_063262325.1 → XP_063118395.1  tandem C2 domains nuclear protein isoform X1

  12. XM_063262324.1 → XP_063118394.1  tandem C2 domains nuclear protein isoform X1

  13. XM_063262327.1 → XP_063118397.1  tandem C2 domains nuclear protein isoform X1

  14. XM_063262328.1 → XP_063118398.1  tandem C2 domains nuclear protein isoform X1

  15. XM_063262330.1 → XP_063118400.1  tandem C2 domains nuclear protein isoform X3

  16. XM_063262326.1 → XP_063118396.1  tandem C2 domains nuclear protein isoform X1

  17. XM_039112746.2 → XP_038968674.2  tandem C2 domains nuclear protein isoform X1

  18. XM_039112753.2 → XP_038968681.2  tandem C2 domains nuclear protein isoform X5

  19. XM_039112754.2 → XP_038968682.2  tandem C2 domains nuclear protein isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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