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Cdca4 cell division cycle associated 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500727, updated on 2-Nov-2024

Summary

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Symbol
Cdca4provided by RGD
Full Name
cell division cycle associated 4provided by RGD
Primary source
RGD:1563593
See related
EnsemblRapid:ENSRNOG00000013898 AllianceGenome:RGD:1563593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in cell division. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDCA4 (cell division cycle associated 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 169.7), Spleen (RPKM 112.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdca4 in Genome Data Viewer
Location:
6q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137713390..137722652, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131892305..131901571, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137396133..137421283, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene AHNAK nucleoprotein 2 Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene G protein-coupled receptor 132 Neighboring gene keratin-associated protein 5-9-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Bennetts JS, et al. Gene, 2006 Jun 7. PMID 16546331
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124732

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division cycle-associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037214.1 → NP_001032291.1  cell division cycle-associated protein 4

    See identical proteins and their annotated locations for NP_001032291.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107668
    UniProtKB/TrEMBL
    Q3B7C7
    Related
    ENSRNOP00000088867.1, ENSRNOT00000100777.2
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 68
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    137713390..137722652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112764.2 → XP_038968692.1  cell division cycle-associated protein 4 isoform X1

    UniProtKB/TrEMBL
    M0R698
    Related
    ENSRNOP00000064942.2, ENSRNOT00000018596.7
    Conserved Domains (1) summary
    pfam06031
    Location:39 → 74
    SERTA; SERTA motif

  2. XM_039112763.2 → XP_038968691.1  cell division cycle-associated protein 4 isoform X1

    UniProtKB/TrEMBL
    M0R698
    Conserved Domains (1) summary
    pfam06031
    Location:39 → 74
    SERTA; SERTA motif

  3. XM_008764948.4 → XP_008763170.1  cell division cycle-associated protein 4 isoform X2

    See identical proteins and their annotated locations for XP_008763170.1

    UniProtKB/TrEMBL
    Q3B7C7
    Related
    ENSRNOP00000100496.1, ENSRNOT00000155559.1
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 68
    SERTA; SERTA motif
Nucleotide Protein Strain
Heading Accession and Version

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