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Rgs22 regulator of G-protein signaling 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500853, updated on 10-Jul-2024

Summary

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Official Symbol
Rgs22provided by RGD
Official Full Name
regulator of G-protein signaling 22provided by RGD
Primary source
RGD:1565493
See related
EnsemblRapid:ENSRNOG00000025551 AllianceGenome:RGD:1565493
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565493
Summary
Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in actin cytoskeleton; cytosol; and fibrillar center. Orthologous to human RGS22 (regulator of G protein signaling 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 381.1), Lung (RPKM 74.0) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rgs22 in Genome Data Viewer
Location:
7q22
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (69073681..69194041, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (67188531..67308805, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (74783009..74902049, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA-splicing factor CWC22 homolog Neighboring gene ribosomal protein S24, pseudogene 17 Neighboring gene uncharacterized LOC134479892 Neighboring gene F-box protein 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Hu Y, et al. Biol Reprod, 2008 Dec. PMID 18703424
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 22

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    69073681..69194041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264609.1 → XP_063120679.1  regulator of G-protein signaling 22 isoform X5

    Related
    ENSRNOP00000095785.2, ENSRNOT00000112997.2

  2. XM_039080154.2 → XP_038936082.1  regulator of G-protein signaling 22 isoform X3

    Conserved Domains (3) summary
    cd08725
    Location:1005 → 1127
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:832 → 961
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cl02565
    Location:663 → 765
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. XM_039080158.2 → XP_038936086.1  regulator of G-protein signaling 22 isoform X6

    Related
    ENSRNOP00000109370.1, ENSRNOT00000161778.1
    Conserved Domains (3) summary
    cd08726
    Location:845 → 974
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:663 → 778
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:997 → 1086
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. XM_039080157.2 → XP_038936085.1  regulator of G-protein signaling 22 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AM59
    Conserved Domains (3) summary
    cd08725
    Location:1018 → 1140
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:845 → 974
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:663 → 778
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

  5. XM_006241548.5 → XP_006241610.1  regulator of G-protein signaling 22 isoform X1

    UniProtKB/TrEMBL
    F1LX91
    Related
    ENSRNOP00000034120.4, ENSRNOT00000039378.6
    Conserved Domains (3) summary
    cd08725
    Location:1018 → 1140
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:845 → 974
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:663 → 778
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

  6. XM_063264607.1 → XP_063120677.1  regulator of G-protein signaling 22 isoform X2

  7. XM_039080159.2 → XP_038936087.1  regulator of G-protein signaling 22 isoform X7

    Conserved Domains (3) summary
    cd08725
    Location:569 → 691
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:396 → 525
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:214 → 329
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

RNA

  1. XR_010053752.1 RNA Sequence

  2. XR_010053751.1 RNA Sequence

Nucleotide Protein Strain
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