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Arhgap39 Rho GTPase activating protein 39 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500901, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap39provided by RGD
Official Full Name
Rho GTPase activating protein 39provided by RGD
Primary source
RGD:1593158
See related
EnsemblRapid:ENSRNOG00000016566 AllianceGenome:RGD:1593158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Porf-2
Summary
Predicted to be involved in postsynapse organization. Is active in glutamatergic synapse and postsynapse. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 66.1), Spleen (RPKM 57.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap39 in Genome Data Viewer
Location:
7q34
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110326918..110419500, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108446280..108538875, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117788716..117880329, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene RecQ like helicase 4 Neighboring gene leucine rich repeat containing 14 Neighboring gene similar to human chromosome 8 open reading frame 82 Neighboring gene leucine rich repeat containing 24 Neighboring gene uncharacterized LOC134479930 Neighboring gene zinc finger protein 251

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of two hypothalamic cDNAs encoding tissue-specific transcripts in the preoptic area and testis. Nowak FV. Mol Endocrinol, 1990 Aug. PMID 2293025
  2. The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons. Lim J, et al. Curr Biol, 2014 Mar 31. PMID 24656827, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA1688

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rho GTPase-activating protein 39
Names
preoptic regulatory factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173122.3 → NP_775145.2  rho GTPase-activating protein 39

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HSD4, F1LR18
    Related
    ENSRNOP00000051450.3, ENSRNOT00000052227.5
    Conserved Domains (3) summary
    PRK10263
    Location:219 → 378
    PRK10263; DNA translocase FtsK; Provisional
    cd04389
    Location:914 → 1099
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 903
    MyTH4; MyTH4 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110326918..110419500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241866.5 → XP_006241928.1  rho GTPase-activating protein 39 isoform X2

    UniProtKB/TrEMBL
    A6HSD4
    Related
    ENSRNOP00000111124.1, ENSRNOT00000168992.1
    Conserved Domains (2) summary
    cd04389
    Location:886 → 1071
    RhoGAP_KIAA1688; RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into ...
    cl02480
    Location:689 → 874
    MyTH4; MyTH4 domain

  2. XM_006241867.5 → XP_006241929.1  rho GTPase-activating protein 39 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y0P2, A6HSD4
    Related
    ENSRNOP00000076721.1, ENSRNOT00000104965.2
    Conserved Domains (3) summary
    PRK10263
    Location:219 → 378
    PRK10263; DNA translocase FtsK; Provisional
    cd04389
    Location:883 → 1068
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 872
    MyTH4; MyTH4 domain

  3. XM_017595054.3 → XP_017450543.1  rho GTPase-activating protein 39 isoform X1

    UniProtKB/TrEMBL
    A6HSD4, F1LR18
    Conserved Domains (3) summary
    PRK10263
    Location:219 → 378
    PRK10263; DNA translocase FtsK; Provisional
    cd04389
    Location:914 → 1099
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 903
    MyTH4; MyTH4 domain

  4. XM_039079761.2 → XP_038935689.1  rho GTPase-activating protein 39 isoform X1

    UniProtKB/TrEMBL
    A6HSD4, F1LR18
    Conserved Domains (3) summary
    PRK10263
    Location:219 → 378
    PRK10263; DNA translocase FtsK; Provisional
    cd04389
    Location:914 → 1099
    RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
    pfam00784
    Location:762 → 903
    MyTH4; MyTH4 domain

  5. XM_063264134.1 → XP_063120204.1  rho GTPase-activating protein 39 isoform X4

  6. XM_063264135.1 → XP_063120205.1  rho GTPase-activating protein 39 isoform X7

  7. XM_039079762.2 → XP_038935690.1  rho GTPase-activating protein 39 isoform X5

    Conserved Domains (2) summary
    PRK10263
    Location:219 → 378
    PRK10263; DNA translocase FtsK; Provisional
    pfam00784
    Location:762 → 891
    MyTH4; MyTH4 domain

  8. XM_017595056.3 → XP_017450545.2  rho GTPase-activating protein 39 isoform X6

    Conserved Domains (2) summary
    PRK10263
    Location:219 → 378
    PRK10263; DNA translocase FtsK; Provisional
    pfam00784
    Location:762 → 846
    MyTH4; MyTH4 domain

RNA

  1. XR_005486709.2 RNA Sequence

  2. XR_005486708.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18890.2 GenPept UniProtKB/Swiss-Prot:P18890

Gene LinkOut

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