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Insyn1 inhibitory synaptic factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501007, updated on 17-Aug-2024

Summary

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Official Symbol
Insyn1provided by RGD
Official Full Name
inhibitory synaptic factor 1provided by RGD
Primary source
RGD:1562618
See related
AllianceGenome:RGD:1562618
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562618
Summary
Predicted to be involved in inhibitory postsynaptic potential. Predicted to be active in postsynaptic density. Orthologous to human INSYN1 (inhibitory synaptic factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 140.8), Kidney (RPKM 76.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Insyn1 in Genome Data Viewer
Location:
8q24
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67799989..67810685)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58904153..58914850)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (63286841..63297080)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094175 Neighboring gene uncharacterized LOC100911193 Neighboring gene Cd276 molecule Neighboring gene neuroplastin Neighboring gene REC114 meiotic recombination protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in chemical synaptic transmission, postsynaptic ISO
Inferred from Sequence Orthology
more info
  
involved_in inhibitory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in postsynaptic specialization organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitory synaptic factor 1
Names
UPF0583 protein C15orf59 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113791.1 → NP_001107263.1  inhibitory synaptic factor 1

    See identical proteins and their annotated locations for NP_001107263.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158644
    UniProtKB/Swiss-Prot
    B0BN13
    UniProtKB/TrEMBL
    A6J508
    Conserved Domains (1) summary
    pfam15252
    Location:52 → 278
    DUF4589; Domain of unknown function (DUF4589)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    67799989..67810685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BN13.1 GenPept UniProtKB/Swiss-Prot:B0BN13

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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