U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cfc1 cripto, FRL-1, cryptic family 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501121, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cfc1provided by RGD
Official Full Name
cripto, FRL-1, cryptic family 1provided by RGD
Primary source
RGD:1562188
See related
EnsemblRapid:ENSRNOG00000042646 AllianceGenome:RGD:1562188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562188
Summary
Predicted to enable activin receptor binding activity and nodal binding activity. Involved in female pregnancy. Predicted to be active in cell surface and extracellular region. Human ortholog(s) of this gene implicated in tetralogy of Fallot and visceral heterotaxy. Orthologous to human CFC1 (cryptic, EGF-CFC family member 1) and CFC1B (cryptic, EGF-CFC family member 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 9.1), Lung (RPKM 5.0) and 2 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cfc1 in Genome Data Viewer
Location:
9q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44234997..44247846)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36742106..36751931)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41045352..41051979)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene uncharacterized LOC134480354 Neighboring gene protease, serine, 39 Neighboring gene small nucleolar RNA, H/ACA box 51 Neighboring gene protease, serine, 40 Neighboring gene RCC1 and BTB domain containing protein 1, pseudogene 1 Neighboring gene APC membrane recruitment protein 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot. Sheng W, et al. J Transl Med, 2014 Jan 31. PMID 24479926, Free PMC Article
  2. Duplication and deletion of CFC1 associated with heterotaxy syndrome. Cao R, et al. DNA Cell Biol, 2015 Feb. PMID 25423076, Free PMC Article
  3. Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo. Argañaraz ME, et al. Mol Reprod Dev, 2019 Nov. PMID 31418961
  4. Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Bamford RN, et al. Nat Genet, 2000 Nov. PMID 11062482
  5. A role of the cryptic gene in the correct establishment of the left-right axis. Gaio U, et al. Curr Biol, 1999 Nov 18. PMID 10574770

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables activin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nodal binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
  
involved_in determination of left/right symmetry IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
  
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within left lung morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
  
involved_in nodal signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nodal signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spleen development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cryptic protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109304.2 → NP_001102774.2  cryptic protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6GC89
    Related
    ENSRNOP00000062738.4, ENSRNOT00000066284.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    44234997..44247846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267584.1 → XP_063123654.1  cryptic protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GC89
    Related
    ENSRNOP00000084880.1, ENSRNOT00000104316.2

  2. XM_039084069.2 → XP_038939997.1  cryptic protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GC89, A6INA5, F1LV65
    Conserved Domains (2) summary
    cd00054
    Location:99 → 123
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam09443
    Location:131 → 165
    CFC; Cripto_Frl-1_Cryptic (CFC)

  3. XM_063267583.1 → XP_063123653.1  cryptic protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GC89
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools