Mreg melanoregulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mregprovided by RGD
Official Full Name: melanoregulinprovided by RGD
Primary source: RGD:1562333
See related: EnsemblRapid:ENSRNOG00000015774 AllianceGenome:RGD:1562333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562333
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including melanocyte differentiation; melanosome transport; and minus-end-directed organelle transport along microtubule. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be intrinsic component of organelle membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. Orthologous to human MREG (melanoregulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 388.1), Muscle (RPKM 112.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (81236019..81291601, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (73786727..73842081, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (79490058..79559768, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137578 (e-PCR)
- UniSTS:219665

d9rat72 (e-PCR)
- UniSTS:122554

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental pigmentation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanosome localization	ISO Inferred from Sequence Orthology more info
involved_in melanosome transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in minus-end-directed organelle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in phagosome maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanoregulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.