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Gmppa GDP-mannose pyrophosphorylase A [ Rattus norvegicus (Norway rat) ]

Gene ID: 501167, updated on 2-Nov-2024

Summary

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Symbol
Gmppaprovided by RGD
Full Name
GDP-mannose pyrophosphorylase Aprovided by RGD
Primary source
RGD:1560644
See related
EnsemblRapid:ENSRNOG00000019946 AllianceGenome:RGD:1560644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity and enzyme inhibitor activity. Predicted to be involved in several processes, including negative regulation of nucleobase-containing compound metabolic process; negative regulation of phosphorus metabolic process; and negative regulation of small molecule metabolic process. Predicted to act upstream of or within several processes, including GDP-mannose biosynthetic process; motor behavior; and protein glycosylation. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 145.3), Kidney (RPKM 111.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gmppa in Genome Data Viewer
Location:
9q33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84375373..84382917)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76926724..76934274)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82632267..82639811)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550477 Neighboring gene desmin Neighboring gene striated muscle enriched protein kinase Neighboring gene uncharacterized LOC120094713 Neighboring gene uncharacterized LOC108351955 Neighboring gene uncharacterized LOC120094714 Neighboring gene acid sensing ion channel subunit family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues. Verachtert H, et al. J Biol Chem, 1966 May 10. PMID 5946626
  2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables mannose-1-phosphate guanylyltransferase (GTP) activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GDP-mannose biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within GDP-mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP-mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cognition IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cognition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in motor behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within motor behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle organ morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nucleobase-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phosphorus metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of small molecule metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuromuscular process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle organ development ISO
Inferred from Sequence Orthology
more info
  
involved_in telencephalon development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within telencephalon development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GDP-mannose pyrophosphorylase complex IEA
Inferred from Electronic Annotation
more info
  
part_of GDP-mannose pyrophosphorylase complex ISO
Inferred from Sequence Orthology
more info
  
part_of GDP-mannose pyrophosphorylase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mannose-1-phosphate guanylyltransferase regulatory subunit alpha; mannose-1-phosphate guanyltransferase alpha
Names
GTP-mannose-1-phosphate guanylyltransferase alpha
NP_001020227.1
XP_006245333.1
XP_063123697.1
XP_063123698.1
XP_063123700.1
XP_063123701.1
XP_063123702.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025056.2 → NP_001020227.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha

    See identical proteins and their annotated locations for NP_001020227.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIC1
    UniProtKB/TrEMBL
    A0A8I5ZKL2, A6JW33
    Conserved Domains (3) summary
    cd06428
    Location:4 → 261
    M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
    COG1208
    Location:1 → 349
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:289 → 355
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  2. NM_001432721.1 → NP_001419650.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIC1
    UniProtKB/TrEMBL
    A6JW33

  3. NM_001432722.1 → NP_001419651.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIC1
    UniProtKB/TrEMBL
    A6JW33

  4. NM_001432723.1 → NP_001419652.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIC1
    UniProtKB/TrEMBL
    A6JW33

  5. NM_001432724.1 → NP_001419653.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIC1
    UniProtKB/TrEMBL
    A6JW33

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    84375373..84382917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245271.4 → XP_006245333.1  mannose-1-phosphate guanyltransferase alpha isoform X1

    Conserved Domains (3) summary
    cd06428
    Location:4 → 261
    M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
    COG1208
    Location:1 → 349
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:289 → 355
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  2. XM_063267630.1 → XP_063123700.1  mannose-1-phosphate guanyltransferase alpha isoform X1

  3. XM_063267627.1 → XP_063123697.1  mannose-1-phosphate guanyltransferase alpha isoform X1

    Related
    ENSRNOP00000027064.3, ENSRNOT00000027064.6

  4. XM_063267628.1 → XP_063123698.1  mannose-1-phosphate guanyltransferase alpha isoform X1

  5. XM_063267632.1 → XP_063123702.1  mannose-1-phosphate guanyltransferase alpha isoform X2

  6. XM_063267631.1 → XP_063123701.1  mannose-1-phosphate guanyltransferase alpha isoform X1

    UniProtKB/Swiss-Prot
    Q5XIC1
    UniProtKB/TrEMBL
    A6JW33

RNA

  1. XR_010054629.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIC1.1 GenPept UniProtKB/Swiss-Prot:Q5XIC1

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