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Vwc2 von Willebrand factor C domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501231, updated on 2-Nov-2024

Summary

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Official Symbol
Vwc2provided by RGD
Official Full Name
von Willebrand factor C domain containing 2provided by RGD
Primary source
RGD:1589624
See related
EnsemblRapid:ENSRNOG00000049076 AllianceGenome:RGD:1589624
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of BMP signaling pathway; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of neuron differentiation. Predicted to act upstream of or within positive regulation of cell-substrate adhesion. Predicted to be located in basement membrane and interstitial matrix. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space and glutamatergic synapse. Predicted to be extrinsic component of postsynaptic membrane. Orthologous to human VWC2 (von Willebrand factor C domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 24.0), Testes (RPKM 4.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vwc2 in Genome Data Viewer
Location:
14q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (89897543..90038732)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (85683670..85825068)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (91201141..91348219)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1, pseudogene 5 Neighboring gene cellular tumor antigen p53-like Neighboring gene ribosomal protein L9, pseudogene 27 Neighboring gene uncharacterized LOC102552528 Neighboring gene zona pellucida binding protein Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC120096664 Neighboring gene sperm microtubule inner protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. Koike N, et al. J Biol Chem, 2007 May 25. PMID 17400546
  2. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720
  3. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in interstitial matrix ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
brorin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109312.1 → NP_001102782.1  brorin precursor

    See identical proteins and their annotated locations for NP_001102782.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474055
    UniProtKB/TrEMBL
    A6KJ97, M0RB53
    Related
    ENSRNOP00000066776.1, ENSRNOT00000071558.3
    Conserved Domains (1) summary
    cl17735
    Location:217 → 272
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    89897543..90038732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092332.2 → XP_038948260.1  brorin isoform X2

  2. XM_017599335.3 → XP_017454824.1  brorin isoform X1

    UniProtKB/TrEMBL
    A6KJ97, M0RB53
    Conserved Domains (1) summary
    cl17735
    Location:217 → 272
    VWC; von Willebrand factor type C domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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