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Agk acylglycerol kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 502749, updated on 2-Nov-2024

Summary

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Official Symbol
Agkprovided by RGD
Official Full Name
acylglycerol kinaseprovided by RGD
Primary source
RGD:1562046
See related
EnsemblRapid:ENSRNOG00000011509 AllianceGenome:RGD:1562046
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562046
Summary
Predicted to enable ATP-dependent diacylglycerol kinase activity; acylglycerol kinase activity; and ceramide kinase activity. Predicted to be involved in ceramide biosynthetic process and protein insertion into mitochondrial inner membrane. Predicted to act upstream of or within lipid phosphorylation. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 66.2), Thymus (RPKM 64.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Agk in Genome Data Viewer
Location:
4q23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (70081550..70160642)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (69114850..69193989)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (68483345..68561518)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692103 Neighboring gene transmembrane protein 178B Neighboring gene uncharacterized LOC102555151 Neighboring gene DENN domain containing 11 Neighboring gene WEE2 oocyte meiosis inhibiting kinase Neighboring gene single stranded DNA binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. Bektas M, et al. J Cell Biol, 2005 Jun 6. PMID 15939762, Free PMC Article
  2. MuLK, a eukaryotic multi-substrate lipid kinase. Waggoner DW, et al. J Biol Chem, 2004 Sep 10. PMID 15252046
  3. Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy. Abu El-Asrar AM, et al. Acta Diabetol, 2013 Jun. PMID 22864860
  4. Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex. Kang Y, et al. Mol Cell, 2017 Aug 3. PMID 28712726
  5. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. Van Overloop H, et al. J Lipid Res, 2006 Feb. PMID 16269826

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our findings suggest that ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy.
    Title: Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables acylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acylglycerol kinase, mitochondrial
NP_001120969.1
XP_008761043.1
XP_017448334.1
XP_017448335.1
XP_038964167.1
XP_038964168.1
XP_038964169.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127497.1 → NP_001120969.1  acylglycerol kinase, mitochondrial

    See identical proteins and their annotated locations for NP_001120969.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    A6IEW6, D3Z9L0
    Related
    ENSRNOP00000111857.1, ENSRNOT00000134748.1
    Conserved Domains (1) summary
    pfam00781
    Location:62 → 195
    DAGK_cat; Diacylglycerol kinase catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    70081550..70160642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108239.2 → XP_038964167.1  acylglycerol kinase, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam00781
    Location:62 → 195
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. XM_017592846.3 → XP_017448335.1  acylglycerol kinase, mitochondrial isoform X3

    Related
    ENSRNOP00000107145.1, ENSRNOT00000122767.1
    Conserved Domains (1) summary
    pfam00781
    Location:26 → 159
    DAGK_cat; Diacylglycerol kinase catalytic domain

  3. XM_017592845.3 → XP_017448334.1  acylglycerol kinase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6IEW6, D3Z9L0
    Conserved Domains (1) summary
    pfam00781
    Location:62 → 195
    DAGK_cat; Diacylglycerol kinase catalytic domain

  4. XM_039108240.2 → XP_038964168.1  acylglycerol kinase, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam00781
    Location:26 → 159
    DAGK_cat; Diacylglycerol kinase catalytic domain

  5. XM_008762821.4 → XP_008761043.1  acylglycerol kinase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_008761043.1

    UniProtKB/TrEMBL
    A6IEW6, D3Z9L0
    Related
    ENSRNOP00000108388.1, ENSRNOT00000137915.1
    Conserved Domains (1) summary
    pfam00781
    Location:62 → 195
    DAGK_cat; Diacylglycerol kinase catalytic domain

  6. XM_039108241.2 → XP_038964169.1  acylglycerol kinase, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam00781
    Location:26 → 159
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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