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Rerg RAS-like, estrogen-regulated, growth-inhibitor [ Rattus norvegicus (Norway rat) ]

Gene ID: 502916, updated on 2-Nov-2024

Summary

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Official Symbol
Rergprovided by RGD
Official Full Name
RAS-like, estrogen-regulated, growth-inhibitorprovided by RGD
Primary source
RGD:1562829
See related
EnsemblRapid:ENSRNOG00000027592 AllianceGenome:RGD:1562829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562829
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in negative regulation of cell growth; negative regulation of cell population proliferation; and response to hormone. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human RERG (RAS like estrogen regulated growth inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 147.6), Lung (RPKM 77.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rerg in Genome Data Viewer
Location:
4q43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171712794..171821268, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169981634..170089777, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (171069161..171176678, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene ubiquitin-like Neighboring gene uncharacterized LOC120102419 Neighboring gene uncharacterized LOC134486652 Neighboring gene uncharacterized LOC134486857 Neighboring gene prohibitin 1, pseudogene 5 Neighboring gene protein tyrosine phosphatase, receptor type, O Neighboring gene uncharacterized LOC120102421

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. Finlin BS, et al. J Biol Chem, 2001 Nov 9. PMID 11533059
  2. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related and estrogen-regulated growth inhibitor
NP_001385858.1
XP_006237644.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398929.1 → NP_001385858.1  ras-related and estrogen-regulated growth inhibitor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IMK1, F1M2G3
    Related
    ENSRNOP00000028930.3, ENSRNOT00000030850.6
    Conserved Domains (1) summary
    cd04146
    Location:8 → 169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    171712794..171821268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237582.4 → XP_006237644.1  ras-related and estrogen-regulated growth inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006237644.1

    UniProtKB/TrEMBL
    A0A8I5ZRS4, A6IMK1, F1M2G3
    Conserved Domains (1) summary
    cd04146
    Location:8 → 169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
Nucleotide Protein Strain
Heading Accession and Version

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