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Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 503027, updated on 18-Sep-2024

Summary

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Official Symbol
Map4k5provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5provided by RGD
Primary source
RGD:1562028
See related
EnsemblRapid:ENSRNOG00000004923 AllianceGenome:RGD:1562028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562028
Summary
Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to be located in cytoplasm. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 139.9), Brain (RPKM 135.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Map4k5 in Genome Data Viewer
Location:
6q24
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (94020079..94112943, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88284087..88377118, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92136242..92229578, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene distal membrane arm assembly component 2 like Neighboring gene uncharacterized LOC102548655 Neighboring gene cyclin dependent kinase like 1 Neighboring gene atlastin GTPase 1 Neighboring gene salvador family WW domain containing protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Tung RM, et al. Oncogene, 1997 Feb 13. PMID 9038372
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 5
NP_001178945.1
XP_006240242.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192016.2 → NP_001178945.1  mitogen-activated protein kinase kinase kinase kinase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AJ75, D3ZHL6
    Related
    ENSRNOP00000006705.6, ENSRNOT00000006705.7
    Conserved Domains (3) summary
    smart00036
    Location:511 → 826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    94020079..94112943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240180.5 → XP_006240242.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJ75, A6HBX7
    Related
    ENSRNOP00000092920.1, ENSRNOT00000106217.2
    Conserved Domains (3) summary
    smart00036
    Location:511 → 825
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
Nucleotide Protein Strain
Heading Accession and Version

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