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MINK1 misshapen like kinase 1 [ Homo sapiens (human) ]

Gene ID: 50488, updated on 11-Apr-2024

Summary

Official Symbol
MINK1provided by HGNC
Official Full Name
misshapen like kinase 1provided by HGNC
Primary source
HGNC:HGNC:17565
See related
Ensembl:ENSG00000141503 MIM:609426; AllianceGenome:HGNC:17565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B55; ZC3; MINK; YSK2; MAP4K6; MEKKK 6
Summary
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in skin (RPKM 48.7), brain (RPKM 31.3) and 25 other tissues See more
Orthologs
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Genomic context

Location:
17p13.2
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4833340..4898061)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4722898..4788313)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4736635..4801356)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8045 Neighboring gene chromosome 17 open reading frame 114 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4711183-4712382 Neighboring gene phospholipase D2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4735692-4736478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4752245-4752960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4752961-4753674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:4757141-4758092 Neighboring gene Sharpr-MPRA regulatory region 481 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11550 Neighboring gene RNA, 7SL, cytoplasmic 784, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4805105-4805746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4805747-4806388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11552 Neighboring gene Sharpr-MPRA regulatory region 10924 Neighboring gene chromosome 17 open reading frame 107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4811144-4811970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4811971-4812796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4812797-4813623 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11554 Neighboring gene glycoprotein Ib platelet subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC21111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in JNK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
misshapen-like kinase 1
Names
GCK family kinase MINK
MAPK/ERK kinase kinase kinase 6
MEK kinase kinase 6
misshapen/NIK-related kinase
mitogen-activated protein kinase kinase kinase kinase 6
NP_001020108.1
NP_001308165.1
NP_056531.1
NP_722549.2
NP_733763.1
XP_006721594.1
XP_006721595.1
XP_006721599.1
XP_011522208.1
XP_016880193.1
XP_016880194.1
XP_016880195.1
XP_016880196.1
XP_016880197.1
XP_047292121.1
XP_047292122.1
XP_047292123.1
XP_047292124.1
XP_047292125.1
XP_047292126.1
XP_047292127.1
XP_047292128.1
XP_047292129.1
XP_047292130.1
XP_047292131.1
XP_047292132.1
XP_047292133.1
XP_047292134.1
XP_047292135.1
XP_054172280.1
XP_054172281.1
XP_054172282.1
XP_054172283.1
XP_054172284.1
XP_054172285.1
XP_054172286.1
XP_054172287.1
XP_054172288.1
XP_054172289.1
XP_054172290.1
XP_054172291.1
XP_054172292.1
XP_054172293.1
XP_054172294.1
XP_054172295.1
XP_054172296.1
XP_054172297.1
XP_054172298.1
XP_054172299.1
XP_054172300.1
XP_054172301.1
XP_054172302.1
XP_054172303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028005.1 RefSeqGene

    Range
    5001..69722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024937.4NP_001020108.1  misshapen-like kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_001020108.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini and is longer compared to isoform 1.
    Source sequence(s)
    AB041926, AL157418, AY775058, DA653105
    Consensus CDS
    CCDS45590.1
    UniProtKB/Swiss-Prot
    Q8N4C8
    Related
    ENSP00000406487.3, ENST00000453408.7
    Conserved Domains (3) summary
    smart00036
    Location:9941292
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  2. NM_001321236.2NP_001308165.1  misshapen-like kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB041926, AL157418, BC094686, DA653105
    UniProtKB/Swiss-Prot
    Q8N4C8
    Conserved Domains (3) summary
    smart00036
    Location:9221220
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:11234
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1234
    PKc_like; Protein Kinases, catalytic domain
  3. NM_015716.5NP_056531.1  misshapen-like kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_056531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AB035698, AB041926, AL157418, DA653105
    UniProtKB/Swiss-Prot
    Q8N4C8
    Conserved Domains (3) summary
    smart00036
    Location:9771275
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  4. NM_153827.5NP_722549.2  misshapen-like kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_722549.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an additional in-frame exon, compared to variant 1, resulting in the longest isoform (3) which has a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AB035698, AB041926, AL157418, BC034673, DA653105
    Consensus CDS
    CCDS45588.1
    UniProtKB/Swiss-Prot
    D3DTK3, D3DTK4, Q5U8Z0, Q8N4C8, Q9P1X1, Q9P2R8
    Related
    ENSP00000347427.6, ENST00000355280.11
    Conserved Domains (3) summary
    smart00036
    Location:10141312
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  5. NM_170663.5NP_733763.1  misshapen-like kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_733763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an additional in-frame exon, compared to variant 1, resulting in a longer isoform (2) that has a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AB041926, AL157418, DA653105
    Consensus CDS
    CCDS45589.1
    UniProtKB/Swiss-Prot
    Q8N4C8
    Related
    ENSP00000269296.7, ENST00000347992.11
    Conserved Domains (3) summary
    smart00036
    Location:9851283
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4833340..4898061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721531.2XP_006721594.1  misshapen-like kinase 1 isoform X1

    Conserved Domains (3) summary
    smart00036
    Location:10431341
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  2. XM_006721532.2XP_006721595.1  misshapen-like kinase 1 isoform X2

    Conserved Domains (3) summary
    smart00036
    Location:10421340
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  3. XM_006721536.2XP_006721599.1  misshapen-like kinase 1 isoform X11

    Conserved Domains (3) summary
    smart00036
    Location:10061304
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  4. XM_017024706.1XP_016880195.1  misshapen-like kinase 1 isoform X12

  5. XM_017024705.1XP_016880194.1  misshapen-like kinase 1 isoform X5

  6. XM_047436166.1XP_047292122.1  misshapen-like kinase 1 isoform X6

  7. XM_047436168.1XP_047292124.1  misshapen-like kinase 1 isoform X8

  8. XM_047436173.1XP_047292129.1  misshapen-like kinase 1 isoform X17

  9. XM_047436170.1XP_047292126.1  misshapen-like kinase 1 isoform X13

  10. XM_047436176.1XP_047292132.1  misshapen-like kinase 1 isoform X21

  11. XM_047436177.1XP_047292133.1  misshapen-like kinase 1 isoform X22

  12. XM_017024704.1XP_016880193.1  misshapen-like kinase 1 isoform X3

  13. XM_047436165.1XP_047292121.1  misshapen-like kinase 1 isoform X4

  14. XM_047436167.1XP_047292123.1  misshapen-like kinase 1 isoform X7

  15. XM_011523906.1XP_011522208.1  misshapen-like kinase 1 isoform X9

    Conserved Domains (3) summary
    smart00036
    Location:10111309
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  16. XM_047436169.1XP_047292125.1  misshapen-like kinase 1 isoform X10

  17. XM_047436174.1XP_047292130.1  misshapen-like kinase 1 isoform X18

  18. XM_047436175.1XP_047292131.1  misshapen-like kinase 1 isoform X19

  19. XM_047436171.1XP_047292127.1  misshapen-like kinase 1 isoform X14

  20. XM_047436172.1XP_047292128.1  misshapen-like kinase 1 isoform X15

  21. XM_047436178.1XP_047292134.1  misshapen-like kinase 1 isoform X23

    Related
    ENST00000572330.5
  22. XM_047436179.1XP_047292135.1  misshapen-like kinase 1 isoform X24

  23. XM_017024708.2XP_016880197.1  misshapen-like kinase 1 isoform X20

  24. XM_017024707.3XP_016880196.1  misshapen-like kinase 1 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4722898..4788313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316305.1XP_054172280.1  misshapen-like kinase 1 isoform X1

  2. XM_054316306.1XP_054172281.1  misshapen-like kinase 1 isoform X2

  3. XM_054316315.1XP_054172290.1  misshapen-like kinase 1 isoform X11

  4. XM_054316316.1XP_054172291.1  misshapen-like kinase 1 isoform X12

  5. XM_054316309.1XP_054172284.1  misshapen-like kinase 1 isoform X5

  6. XM_054316310.1XP_054172285.1  misshapen-like kinase 1 isoform X6

  7. XM_054316312.1XP_054172287.1  misshapen-like kinase 1 isoform X8

  8. XM_054316321.1XP_054172296.1  misshapen-like kinase 1 isoform X17

  9. XM_054316317.1XP_054172292.1  misshapen-like kinase 1 isoform X13

  10. XM_054316325.1XP_054172300.1  misshapen-like kinase 1 isoform X21

  11. XM_054316326.1XP_054172301.1  misshapen-like kinase 1 isoform X22

  12. XM_054316307.1XP_054172282.1  misshapen-like kinase 1 isoform X3

  13. XM_054316308.1XP_054172283.1  misshapen-like kinase 1 isoform X4

  14. XM_054316311.1XP_054172286.1  misshapen-like kinase 1 isoform X7

  15. XM_054316313.1XP_054172288.1  misshapen-like kinase 1 isoform X9

  16. XM_054316314.1XP_054172289.1  misshapen-like kinase 1 isoform X10

  17. XM_054316322.1XP_054172297.1  misshapen-like kinase 1 isoform X18

  18. XM_054316323.1XP_054172298.1  misshapen-like kinase 1 isoform X19

  19. XM_054316318.1XP_054172293.1  misshapen-like kinase 1 isoform X14

  20. XM_054316319.1XP_054172294.1  misshapen-like kinase 1 isoform X15

  21. XM_054316327.1XP_054172302.1  misshapen-like kinase 1 isoform X23

  22. XM_054316328.1XP_054172303.1  misshapen-like kinase 1 isoform X24

  23. XM_054316320.1XP_054172295.1  misshapen-like kinase 1 isoform X16

  24. XM_054316324.1XP_054172299.1  misshapen-like kinase 1 isoform X20