U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Npepps aminopeptidase puromycin sensitive [ Rattus norvegicus (Norway rat) ]

Gene ID: 50558, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Npeppsprovided by RGD
Official Full Name
aminopeptidase puromycin sensitiveprovided by RGD
Primary source
RGD:619962
See related
EnsemblRapid:ENSRNOG00000023095 AllianceGenome:RGD:619962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Psa
Summary
Enables aminopeptidase activity. Predicted to be involved in several processes, including cellular response to hypoxia; peptide catabolic process; and positive regulation of protein targeting to mitochondrion. Predicted to be located in cytosol. Predicted to be active in cytoplasm; extracellular space; and membrane. Orthologous to human NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 150.6), Heart (RPKM 125.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Npepps in Genome Data Viewer
Location:
10q31
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82687869..82770363, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82191454..82273967, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85140368..85222861, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TBK1 binding protein 1 Neighboring gene karyopherin subunit beta 1 Neighboring gene uncharacterized LOC134480862 Neighboring gene uncharacterized LOC134480863 Neighboring gene mitochondrial ribosomal protein L45

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development. Hui M, et al. Neurochem Res, 2003 Jun. PMID 12718438
  2. cDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate? Huber G, et al. J Neurochem, 1999 Mar. PMID 10037494
  3. Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment. Mitani T, et al. J Steroid Biochem Mol Biol, 2011 Jan. PMID 21056661
  4. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. Beninga J, et al. J Biol Chem, 1998 Jul 24. PMID 9668046
  5. Two new proteases in the MHC class I processing pathway. Stoltze L, et al. Nat Immunol, 2000 Nov. PMID 11062501

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a study of the levels in rat cerebellar development
    Title: Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
puromycin-sensitive aminopeptidase
NP_536320.1
XP_017452967.1
XP_038942585.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080395.1 → NP_536320.1  puromycin-sensitive aminopeptidase

    Status: VALIDATED

    Source sequence(s)
    AB062596, BC105844, CA503636, CA510536, CA512355, DV216619, DY316730, H32677
    UniProtKB/TrEMBL
    A6HIJ7, F1M9V7
    Related
    ENSRNOP00000033290.4, ENSRNOT00000031045.7
    Conserved Domains (3) summary
    cd09601
    Location:62 → 505
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:54 → 442
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:580 → 891
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    82687869..82770363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597478.2 → XP_017452967.1  puromycin-sensitive aminopeptidase isoform X1

    UniProtKB/TrEMBL
    A6HIJ7
    Conserved Domains (2) summary
    cd09601
    Location:1 → 344
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:423 → 736
    ERAP1_C; ERAP1-like C-terminal domain

  2. XM_039086657.2 → XP_038942585.1  puromycin-sensitive aminopeptidase isoform X1

    UniProtKB/TrEMBL
    A6HIJ7
    Conserved Domains (2) summary
    cd09601
    Location:1 → 344
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:423 → 736
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous