Pde3a phosphodiesterase 3A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pde3aprovided by RGD
Official Full Name: phosphodiesterase 3Aprovided by RGD
Primary source: RGD:61942
See related: EnsemblRapid:ENSRNOG00000025042 AllianceGenome:RGD:61942
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RNPDE3A
Summary: Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity; estrogen binding activity; and nuclear estrogen receptor activity. Involved in negative regulation of apoptotic process; negative regulation of cAMP/PKA signal transduction; and oocyte maturation. Predicted to be located in membrane. Predicted to be active in cytosol. Biomarker of obesity and pulmonary hypertension. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 245.3), Lung (RPKM 86.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (175904276..176170531)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (174172804..174443944)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (175431904..175703844)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.
Title: CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.
Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.
Title: Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.
Phosphodiesterase 3A and Arterial Hypertension.
Title: Phosphodiesterase 3A and Arterial Hypertension.
High cGMP and low PDE3A activity are associated with oocyte meiotic incompetence.
Title: High cGMP and low PDE3A activity are associated with oocyte meiotic incompetence.
PDE3A is a low-affinity and high-velocity enzyme for hydrolysis of cUMP in cardiac myocytes.
Title: cUMP hydrolysis by PDE3A.
Observations suggest that NO modulates PDE3A gene expression via mechanisms dependent upon cGMP synthesis and gene transcription.
Title: Phosphodiesterase 3A expression is modulated by nitric oxide in rat pulmonary artery smooth muscle cells.
Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation.
Title: Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation.
systemic administration of forskolin increased PDE3A, PDE3B, and PDE4D mRNA levels in aortic VSMC and femoral artery VSMC, 2) local delivery of dbcAMP increased PDE3A, PDE3B, and PDE4D3 protein levels in femoral artery VSMC.
Title: Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141641 (e-PCR)
- UniSTS:223634

BE120043 (e-PCR)
- UniSTS:247230

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables cyclic-nucleotide phosphodiesterase activity	TAS Traceable Author Statement more info	PubMed
enables estrogen binding	ISO Inferred from Sequence Orthology more info
enables estrogen binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of oocyte development	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of oocyte development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Names: CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A, cGMP inhibited

NP_059033.1

EC 3.1.4.17

XP_063142693.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.