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Crim1 cysteine rich transmembrane BMP regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 50766, updated on 2-Nov-2024

Summary

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Official Symbol
Crim1provided by MGI
Official Full Name
cysteine rich transmembrane BMP regulator 1provided by MGI
Primary source
MGI:MGI:1354756
See related
Ensembl:ENSMUSG00000024074 AllianceGenome:MGI:1354756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable PDZ domain binding activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; integumental system; and sensory organ. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 22.3), ovary adult (RPKM 19.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Crim1 in Genome Data Viewer
Location:
17 E2- E3; 17 48.09 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (78507602..78684021)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78200233..78376592)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5229 Neighboring gene predicted gene, 32282 Neighboring gene STARR-positive B cell enhancer mm9_chr17:78644738-78645038 Neighboring gene predicted gene, 41620 Neighboring gene predicted gene, 52306 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:78761825-78761978 Neighboring gene fasciculation and elongation protein zeta 2 Neighboring gene STARR-seq mESC enhancer starr_43268 Neighboring gene predicted gene, 32336 Neighboring gene predicted gene, 53960

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Crim1 during murine ocular development. Lovicu FJ, et al. Mech Dev, 2000 Jun. PMID 10842084
  2. Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Pennisi DJ, et al. Dev Dyn, 2007 Feb. PMID 17106887
  3. Loss of renal microvascular integrity in postnatal Crim1 hypomorphic transgenic mice. Wilkinson L, et al. Kidney Int, 2009 Dec. PMID 19776720
  4. Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice. Wilkinson L, et al. J Pathol, 2012 Aug. PMID 22488641
  5. Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation. Phua YL, et al. J Pathol, 2016 Apr. PMID 26800422

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
    Title: Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
  2. Crim1(C140S) mice should serve as a valuable model for investigating the functions of CRIM1 that are unidentified as yet.
    Title: Crim1(C140S) mutant mice reveal the importance of cysteine 140 in the internal region 1 of CRIM1 for its physiological functions.
  3. these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature.
    Title: CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.
  4. Collectively, our data demonstrates that Crim1 is essential for cell-autonomous and paracrine aspects of heart development
    Title: Crim1 has cell-autonomous and paracrine roles during embryonic heart development.
  5. Crim1 regulates integrin signaling in murine lens development
    Title: Crim1 regulates integrin signaling in murine lens development.
  6. CRIM1 is the causative gene for Colobomatous macrophthalmia with microcornea syndrome and is important for eye development.
    Title: CRIM1 haploinsufficiency causes defects in eye development in human and mouse.
  7. Vascular endothelial cell-specific conditional compound heterozygotes for Crim1 and Vegfa exhibit a phenotype that is more severe than each single heterozygote and indistinguishable from that of the conditional homozygotes.
    Title: Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
  8. Report the involvement of both endothelial cells and monocytes in the development of progressive renal fibrosis in Crim1 mutant mice.
    Title: Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins.
  9. Crim1 mutations are associated with defects in papillary development and progression to chronic kidney disease later in life.
    Title: Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice.
  10. Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells.
    Title: Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cysteine-rich motor neuron 1 protein
Names
CRIM-1
cysteine rich transmembrane BMP regulator 1 (chordin like)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414256.1 → NP_001401185.1  cysteine-rich motor neuron 1 protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC103598, AC154366

  2. NM_015800.3 → NP_056615.1  cysteine-rich motor neuron 1 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_056615.1

    Status: VALIDATED

    Source sequence(s)
    AC103598, AC154366
    Consensus CDS
    CCDS28976.1
    UniProtKB/Swiss-Prot
    Q497W4, Q9JLL0
    Related
    ENSMUSP00000108117.3, ENSMUST00000112498.3
    Conserved Domains (4) summary
    smart00121
    Location:37 → 95
    IB; Insulin growth factor-binding protein homologues
    smart00214
    Location:403 → 456
    VWC; von Willebrand factor (vWF) type C domain
    pfam02822
    Location:567 → 592
    Antistasin; Antistasin family
    cl17735
    Location:819 → 873
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    78507602..78684021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524602.4 → XP_006524665.1  cysteine-rich motor neuron 1 protein isoform X2

    Conserved Domains (4) summary
    smart00214
    Location:241 → 294
    VWC; von Willebrand factor (vWF) type C domain
    cl17735
    Location:657 → 711
    VWC; von Willebrand factor type C domain
    pfam00219
    Location:39 → 90
    IGFBP; Insulin-like growth factor binding protein
    pfam02822
    Location:405 → 430
    Antistasin; Antistasin family

  2. XM_030249892.1 → XP_030105752.1  cysteine-rich motor neuron 1 protein isoform X4

    Conserved Domains (4) summary
    smart00214
    Location:81 → 134
    VWC; von Willebrand factor (vWF) type C domain
    cl17735
    Location:497 → 551
    VWC; von Willebrand factor type C domain
    pfam02822
    Location:245 → 270
    Antistasin; Antistasin family
    pfam14828
    Location:307 → 340
    Amnionless

  3. XM_006524603.4 → XP_006524666.1  cysteine-rich motor neuron 1 protein isoform X3

    Conserved Domains (3) summary
    smart00214
    Location:118 → 171
    VWC; von Willebrand factor (vWF) type C domain
    cl17735
    Location:534 → 588
    VWC; von Willebrand factor type C domain
    pfam02822
    Location:282 → 307
    Antistasin; Antistasin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLL0.2 GenPept UniProtKB/Swiss-Prot:Q9JLL0

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