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Orc3 origin recognition complex, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 50793, updated on 2-Nov-2024

Summary

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Official Symbol
Orc3provided by MGI
Official Full Name
origin recognition complex, subunit 3provided by MGI
Primary source
MGI:MGI:1354944
See related
Ensembl:ENSMUSG00000040044 AllianceGenome:MGI:1354944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc3l
Summary
Predicted to enable DNA replication origin binding activity. Acts upstream of or within glial cell proliferation and neural precursor cell proliferation. Predicted to be located in chromatin and nuclear body. Predicted to be part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 7.3), whole brain E14.5 (RPKM 6.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Orc3 in Genome Data Viewer
Location:
4 A5; 4 16.81 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34566781..34614942, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34566781..34614963, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33434 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09910 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34497692-34497879 Neighboring gene akirin 2 Neighboring gene STARR-seq mESC enhancer starr_09912 Neighboring gene arginyl-tRNA synthetase 2, mitochondrial Neighboring gene solute carrier family 35 (CMP-sialic acid transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6160 Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A functional requirement for astroglia in promoting blood vessel development in the early postnatal brain. Ma S, et al. PLoS One, 2012. PMID 23110156, Free PMC Article
  2. Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. Springer J, et al. Cytogenet Cell Genet, 1999. PMID 10702681
  3. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake Y, et al. J Biol Chem, 2005 Apr 1. PMID 15634681
  4. Radial glia regulate Cajal-Retzius cell positioning in the early embryonic cerebral cortex. Kwon HJ, et al. Dev Biol, 2011 Mar 1. PMID 21185282
  5. The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Jaremko MJ, et al. Elife, 2020 Aug 18. PMID 32808929, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear pre-replicative complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 3
Names
origin of replication 3 homolog
origin recognition complex subunit Latheo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159563.1 → NP_001153035.1  origin recognition complex subunit 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, that results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AB190257, AK041216, AK045388, AK086579, BB663298
    Consensus CDS
    CCDS51137.1
    UniProtKB/TrEMBL
    Q3ULT0
    Related
    ENSMUSP00000103777.2, ENSMUST00000108142.8
    Conserved Domains (1) summary
    pfam07034
    Location:25 → 350
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

  2. NM_015824.4 → NP_056639.3  origin recognition complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_056639.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK041216, AK045388, AK086579, BB663298
    Consensus CDS
    CCDS18028.1
    UniProtKB/Swiss-Prot
    A2AMF4, A2AMF5, Q6P8H2, Q8BR83, Q8C395, Q9JK30
    UniProtKB/TrEMBL
    Q3ULT0
    Related
    ENSMUSP00000048319.4, ENSMUST00000048706.10
    Conserved Domains (1) summary
    pfam07034
    Location:25 → 350
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    34566781..34614942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320309.3 → XP_017175798.1  origin recognition complex subunit 3 isoform X2

    Conserved Domains (2) summary
    pfam07034
    Location:3 → 203
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
    pfam18137
    Location:456 → 565
    ORC_WH_C; Origin recognition complex winged helix C-terminal

  2. XM_030253654.2 → XP_030109514.1  origin recognition complex subunit 3 isoform X3

    Conserved Domains (2) summary
    pfam07034
    Location:3 → 203
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
    pfam18137
    Location:455 → 564
    ORC_WH_C; Origin recognition complex winged helix C-terminal

  3. XM_030253653.2 → XP_030109513.1  origin recognition complex subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam07034
    Location:25 → 350
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

  4. XM_011250066.4 → XP_011248368.1  origin recognition complex subunit 3 isoform X4

    Conserved Domains (1) summary
    pfam07034
    Location:25 → 350
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JK30.1 GenPept UniProtKB/Swiss-Prot:Q9JK30

Gene LinkOut

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