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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001162870.2 → NP_001156342.1 spastin isoform 1
See identical proteins and their annotated locations for NP_001156342.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AC169506
- Consensus CDS
-
CCDS50181.1
- UniProtKB/Swiss-Prot
- Q6ZPY6, Q80VE0, Q9CVK0, Q9QYY8
- Related
- ENSMUSP00000024869.7, ENSMUST00000024869.8
- Conserved Domains (4) summary
-
- cd02679
Location:114 → 193
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
- cd19524
Location:341 → 504
- RecA-like_spastin; ATPase domain of spastin
- pfam09336
Location:578 → 610
- Vps4_C; Vps4 C terminal oligomerization domain
- pfam17862
Location:531 → 585
- AAA_lid_3; AAA+ lid domain
-
NM_001357738.2 → NP_001344667.1 spastin isoform 3
Status: VALIDATED
- Source sequence(s)
-
AC169506
- Consensus CDS
-
CCDS89152.1
- UniProtKB/TrEMBL
-
A0A3B2WC92
- Related
- ENSMUSP00000156393.2, ENSMUST00000233611.2
- Conserved Domains (2) summary
-
- COG0464
Location:262 → 562
- SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
- cd02679
Location:114 → 192
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
-
NM_001414036.1 → NP_001400965.1 spastin isoform 4
Status: VALIDATED
- Source sequence(s)
-
AC169506
-
NM_016962.3 → NP_058658.2 spastin isoform 2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
- Source sequence(s)
-
AC169506
- Consensus CDS
-
CCDS89151.1
- UniProtKB/TrEMBL
-
A0A286YE25
- Related
- ENSMUSP00000153469.2, ENSMUST00000224711.2
- Conserved Domains (5) summary
-
- smart00382
Location:371 → 507
- AAA; ATPases associated with a variety of cellular activities
- cd02679
Location:114 → 192
- MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
- pfam00004
Location:375 → 505
- AAA; ATPase family associated with various cellular activities (AAA)
- pfam09336
Location:577 → 609
- Vps4_C; Vps4 C terminal oligomerization domain
- cl21455
Location:338 → 394
- P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000083.7 Reference GRCm39 C57BL/6J
- Range
-
74643805..74698110
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_036160681.1 → XP_036016574.1 spastin isoform X2
- Conserved Domains (4) summary
-
- pfam09336
Location:518 → 550
- Vps4_C; Vps4 C terminal oligomerization domain
- pfam17862
Location:471 → 525
- AAA_lid_3; AAA+ lid domain
- cd19524
Location:281 → 444
- RecA-like_spastin; ATPase domain of spastin
- cl00299
Location:114 → 182
- MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
RNA
-
XR_001782088.3 RNA Sequence
-
XR_004939548.1 RNA Sequence