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GOLGA7 golgin A7 [ Homo sapiens (human) ]

Gene ID: 51125, updated on 3-Nov-2024

Summary

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Official Symbol
GOLGA7provided by HGNC
Official Full Name
golgin A7provided by HGNC
Primary source
HGNC:HGNC:24876
See related
Ensembl:ENSG00000147533 MIM:609453; AllianceGenome:HGNC:24876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP16; GOLGA7A; HSPC041; GOLGA3AP1
Summary
Involved in Golgi to plasma membrane protein transport; peptidyl-L-cysteine S-palmitoylation; and protein stabilization. Acts upstream of or within Golgi to plasma membrane transport. Located in Golgi membrane and Golgi stack. Part of palmitoyltransferase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 33.3), testis (RPKM 26.7) and 25 other tissues See more
Orthologs
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Genomic context

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See GOLGA7 in Genome Data Viewer
Location:
8p11.21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41490396..41510980)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41764091..41784672)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41347915..41368499)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9460 Neighboring gene small nucleolar RNA, C/D box 65B Neighboring gene uncharacterized LOC105379391 Neighboring gene uncharacterized LOC124901938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27284 Neighboring gene keratin 18 pseudogene 37 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19143 Neighboring gene GPAT4 and GINS4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27285 Neighboring gene GINS complex subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Correction to: The interactions of ZDHHC5/GOLGA7 with SARS‑CoV‑2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry. Zeng XT, et al. Virol J, 2022 Feb 3. PMID 35115020, Free PMC Article
  2. Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Wu Z, et al. Signal Transduct Target Ther, 2021 Jun 11. PMID 34117209, Free PMC Article
  3. The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry. Zeng XT, et al. Virol J, 2021 Dec 27. PMID 34961524, Free PMC Article
  4. Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170. Ohta E, et al. J Biol Chem, 2003 Dec 19. PMID 14522980
  5. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. Swarthout JT, et al. J Biol Chem, 2005 Sep 2. PMID 16000296

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
    Title: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  4. results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface
    Title: Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.
  5. Data show that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes.
    Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4876, MGC21096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within Golgi to plasma membrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
part_of palmitoyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of palmitoyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
golgin subfamily A member 7
Names
Golgi complex-associated protein of 16kDa
golgi autoantigen, golgin subfamily a, 7
golgi complex-associated protein of 16 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002296.2 → NP_001002296.1  golgin subfamily A member 7 isoform a

    See identical proteins and their annotated locations for NP_001002296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AC009630, AF068291, AF125102, AV650886, BC001227, BC012032, BG939345
    Consensus CDS
    CCDS34887.1
    UniProtKB/Swiss-Prot
    D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
    UniProtKB/TrEMBL
    A0A8Q3WLM5
    Related
    ENSP00000350378.4, ENST00000357743.9
    Conserved Domains (1) summary
    pfam10256
    Location:12 → 124
    Erf4; Golgin subfamily A member 7/ERF4 family

  2. NM_001174124.2 → NP_001167595.1  golgin subfamily A member 7 isoform b

    See identical proteins and their annotated locations for NP_001167595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 2. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC009630, AK026613, BC001227
    Consensus CDS
    CCDS55226.1
    UniProtKB/TrEMBL
    A0A8Q3WLM5
    Related
    ENSP00000386030.2, ENST00000405786.3
    Conserved Domains (1) summary
    pfam10256
    Location:12 → 123
    Erf4; Golgin subfamily A member 7/ERF4 family

  3. NM_001362979.1 → NP_001349908.1  golgin subfamily A member 7 isoform a

    Status: VALIDATED

    Source sequence(s)
    AF068291, AF125102, AV650886, BC001227, BG939345, BI546026
    Consensus CDS
    CCDS34887.1
    UniProtKB/Swiss-Prot
    D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
    UniProtKB/TrEMBL
    A0A8Q3WLM5
    Related
    ENSP00000429329.1, ENST00000518270.6
    Conserved Domains (1) summary
    pfam10256
    Location:12 → 124
    Erf4; Golgin subfamily A member 7/ERF4 family

  4. NM_001362980.2 → NP_001349909.1  golgin subfamily A member 7 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF068291, AF125102, AV650886, BC001227, BG939345, BP341683, HY131836
    Consensus CDS
    CCDS34887.1
    UniProtKB/Swiss-Prot
    D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
    UniProtKB/TrEMBL
    A0A8Q3WLM5
    Related
    ENSP00000511570.1, ENST00000694887.1
    Conserved Domains (1) summary
    pfam10256
    Location:12 → 124
    Erf4; Golgin subfamily A member 7/ERF4 family

  5. NM_016099.3 → NP_057183.2  golgin subfamily A member 7 isoform a

    See identical proteins and their annotated locations for NP_057183.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2, and encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AF068291, AF125102, AV650886, BC001227, BC012032, BG939345, BI553491
    Consensus CDS
    CCDS34887.1
    UniProtKB/Swiss-Prot
    D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
    UniProtKB/TrEMBL
    A0A8Q3WLM5
    Related
    ENSP00000510742.1, ENST00000687203.1
    Conserved Domains (1) summary
    pfam10256
    Location:12 → 124
    Erf4; Golgin subfamily A member 7/ERF4 family

RNA

  1. NR_156425.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009630, AF068291, AF125102, AV650886, BC001227, BG939345, BP341683
    Related
    ENST00000694913.1

  2. NR_156426.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF068291, AF125102, AV650886, BC001227, BG939345, HY136581
    Related
    ENST00000520817.6

  3. NR_156427.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF068291, AF125102, AV650886, BC001227, BG939345, HY099624, HY136581
    Related
    ENST00000694863.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    41490396..41510980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    41764091..41784672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z5G4.2 GenPept UniProtKB/Swiss-Prot:Q7Z5G4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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